摘要
溶血磷脂酸是最简单的磷脂 ,是一种细胞间的磷脂信使。它是在血栓形成初期 ,由于血小板被激活而产生、释放 ,它主要由G 蛋白偶联受体通过至少四种G 蛋白介导的信号转导途径发挥其生物学效应。LPA对正常生理及病理状态下的中枢神经系统功能均有影响 ,LPA是中枢神经系统损伤部位出现最早的信号分子之一。提示LPA对于缺血性脑卒中的发生。
Lysophosphatidic acid (LPA) is one of the simplest natural phospholipids. It is an intracellular phospholipid messenger. LPA can be generated and released by activated platelets as a product of the blood clotting process. The biological functions of LPA are mainly mediated by activating special G protein coupled receptors. At least four G protein-mediated signaling pathways have been identified in the action of LPA. LPA is likely to play both physiological and pathological roles in the development and function of the nervous system. LPA is one of the earliest signaling molecule in the lesion area of the central nervous system. So LPA is believed to be very important for genesis and development of ischemic stroke.
出处
《基础医学与临床》
CSCD
北大核心
2003年第1期10-15,共6页
Basic and Clinical Medicine
关键词
溶血磷脂酸
信号转导
受体
神经系统作用
缺血性卒中
lysophosphatidic acid
signal transduction
G protein coupled receptors
action of nervous system
ischemic stroke
