摘要
目的 探讨调制脉冲磁场对大鼠记忆保持及再现能力的影响及其作用机制。方法 采用改良“十”字迷宫法测试磁场对大鼠记忆行为的影响 ;通过电镜观察磁场对大鼠海马组织神经细胞形态的影响。结果 2 0Hz调制脉冲磁场刺激后大鼠记忆再现能力明显降低 (P <0 .0 5) ,刺激后 1h大鼠记忆保持能力明显降低 (P <0 .0 5) ,刺激后 2 4h磁场对记忆保持的影响基本消失 (P >0 .0 5) ,磁场对记忆的影响因记忆内容而异。 2 0Hz调制脉冲磁场刺激后大鼠海马神经元突触形态发生变化。结论 脉冲磁场引起神经突触变化是其影响大鼠记忆能力的主要作用机制之一。
Objective To explore the effect and the mechanism of modulated magnetic pulse fields on memory retention and retrieval ability of rats. Methods The influence of different pulsed magnetic fields on memory performance of rats was evaluated by using cross maze test, the morphological changes of neurons and nerve synapses in the hippocampus of rats were observed by the electronic microscopy. Results The 20 Hz modulated-pulse magnetic field impaired the memory retrieval ability and the memory retention significantly after 1 hour of exposure of the rats to it ( P <0.05), but the influence died down after 24 hours ( P >0.05). These influences on nerve tissues were also observed in rats underwent the 10Hz modulated magnetic stimulation, manifested as an initial increase in ability of memory in the first 24 hours after the stimulation, but no significant difference from the control was found. The influence of magnetic fields on memory depended on what the rats remembered. Conclusion Changes in the nerve synapses may be a main factor of mechanisms of the influence of pulse magnetic fields on memory ability of rats.
出处
《中华物理医学与康复杂志》
CAS
CSCD
北大核心
2003年第2期67-69,共3页
Chinese Journal of Physical Medicine and Rehabilitation
关键词
记忆能力
脉冲磁场
海马
突触
Memory ability
Pulse magnetic field
Hippocampus
Synapse
