摘要
目的 :研究中国南京地区人群中Gβ3基因C82 5T多态性与抗抑郁药的临床疗效是否存在相关性。 方法 :采用聚合酶链式反应 限制性片段长度多态性分析 (PCR RFLP)技术对 15 4例抑郁症患者和 10 0例健康志愿者进行基因型分析 ;用HAMD评定抗抑郁药的疗效。结果 :抑郁症患者Gβ3基因型频率 (CC 2 2 7% ,CT 3 1 8% ,TT 4 4 8% )、等位基因频率 (C 3 8 6% ,T61 4 % ) ;与正常对照组基因型频率 (CC 2 7 0 % ,CT 5 1 0 % ,TT 2 2 0 % )、等位基因频率 (C 5 2 5 % ,T 4 7 5 % )比较具有显著性差异 (P <0 0 0 1,P <0 0 5 ) ;14 0例抗抑郁药显效者Gβ3基因型频率 (CC 2 0 7% ,CT 3 1 4 % ,TT 4 7 9% )、等位基因频率 (C 3 6 4 % ,T63 6% )和 14例药物无效者基因型频率 (CC 4 2 9% ,CT 3 5 7% ,TT 2 1 4 % )、等位基因频率 (C 60 7% ,T 3 9 3 % )比较有显著性差异 (P <0 0 0 1,P <0 0 0 1) ;不同基因型抑郁症患者经 4wkSSRI ,SNRI类抗抑郁药治疗后 ,HAMD总分均显著下降 ,减分率有显著差异 (CC与CT比较 ,P >0 0 5 ;CC与TT比较 ,P <0 0 1;CT与TT比较P <0 0 5 )。结论 :在中国南京地区人群中Gβ3基因C82
AIM: To investigate the relationship between the C825T polymorphism of Gβ3 subunit gene and antidepressant in Chinese population. METHODS: Polymerase chain reaction combined with restriction fragment length polymorphism (PCR RFLP) was used to detect the polymorphism of G protein β3 subunit gene in 154 depressive patients and 100 controls. The depressive states were assessed with Hamilton Depression Rating Scale (HAMD). RESULTS: There were significant difference of the Gβ3 subunit polymorphism genotypes and alleles between 154 depressive patients (CC 22 7%, CT 31 8%, TT 44 8%; C 38 6%, T 61 4%) and 100 controls (CC 27 0%, CT 51 0%, TT 22 0%; C 52 5%, T 47 5%); There were significant differences of the Gβ3 subunit polymorphism genotypes and alleles between 140 patients with drug response (CC 20 7%, CT 31 4%, TT 47 9%; C 36 4%, T 63 6%) and 14 patients without drug response (CC 42 9%, CT 35 7%, TT 21 4%; C 60 7%, T 39 3%). The reductive ratio of HAMD scores were significant differences in depressive patients with different Gβ3 genotype. CONCLUSION: The C825T polymorphism of Gβ3 subunit gene is associated with depression and antidepreessant clinical responses in Chinese population.
出处
《中国临床药学杂志》
CAS
2003年第2期65-68,共4页
Chinese Journal of Clinical Pharmacy
基金
1999年度江苏省教育厅自然科学基金立项项目 编号 :19990 32
