摘要
目的 探讨维生素D受体 (vitaminDreceptor ,VDR)基因多态性与原发性甲状旁腺功能亢进症 (primaryhyperparathyroidism ,PHPT)的关系。方法 应用多聚酶链反应法和限制性内切酶技术检测 30例PHPT患者和 6 0例正常对照组的VDR基因型。结果 VDR基因型在PHPT患者中的分布为BB型 0例 ,Bb型 1例 ( 3 3% ) ,bb型 2 9例 ( 96 7% ) ;正常对照组BB型 2例 ( 3 3% ) ,Bb型 11例( 18 4% ) ,bb型 47例 ( 78 3% )。PHPT患者与对照组BB、Bb、bb基因型分布差异有显著性 (P≤ 0 0 5 )。结论 PHPT与VDR基因多态性有一定关系。
Objective To investigate the polymorphism of the vitamin D receptor(VDR)gene in relation to primary hyperparathyroidism(PHPT). Method Polymerase chain reaction and restriction analysis were used to determine VDR genotypes in 30 patients with PHPT and in normal subjects.ResultsThe frequency distribution of VDR genotypes in PHPT patients was 0 in BB,1(3.3%) in Bb, 29(96.7%) in bb; and in normal persons was 2(3.3%) in BB, 11(18.4%) in Bb, and 47(78.3%) in bb. There was a significant difference between PHPT patients and normal persons in distribution of BB, Bb, bb genotypes (P≤0.05).ConclusionsThere is some distribution alterations of VDR gene polymorphism in PHPT patients.
出处
《中华普通外科杂志》
CSCD
北大核心
2003年第3期171-172,共2页
Chinese Journal of General Surgery
