摘要
目的:探讨甘氨酸对急性坏死性胰腺炎的防治作用。方法:雄性Wistar大鼠随机分为假手术组、胰腺炎组、甘氨酸预处理组和甘氨酸治疗组(lg/kg)。测定6h、12h和24h血清淀粉酶和胰、肺匀浆中谷胱甘肽(GSH)、丙二醛(MDA)水平,观察胰、肺组织学病变并比较各组动物3日生存率。结果:预处理减轻胰、肺损伤程度,甘氨酸治疗不改变胰病变程度,但明显改善肺损伤,二者均可提高生存率。结论:甘氨酸对坏死性胰腺炎及并发的肺损伤有一定防治作用,可能与其抑制白细胞浸润激活有关。
Objective: To investigate the prophylactic and therapeutic effects of glycine on acute necrotizing pancreatitis (ANP). Methods: Male Wistar rats wer edivided randomly into 4 groups: sham operation , ANP, ANP pretreated and post-treateated with intravenous glycine(1g/kg. b. w) immediately and 4 hours after ANP induction . Amylase in serum , glu-tathione(GSH), malondialdehyde (MDA ) and pathologic, chanegs in lung and pancreas were determined at 6 hours, 12 hours ,24 hours after ANP induction . Survival for 3 days were compared among these groups. Results: Glycine pretreating could decrease pancreatic and pulmonary pathologic severiy. Glycine posttreating could ameliorate lung injury while did not improve the pancreaticchanges. Both glycine pretreating and posttreating increased survival. Conclusion: Glycine may be effective in preventing. ANP and associated acute lung injury, or treating probably through inhibition of the infiltration and activation of leukocytes.
出处
《河南外科学杂志》
2003年第2期2-4,共3页
Henan Journal of Surgery
