摘要
目的 探讨他莫昔芬治疗乳腺小叶增生症的疗效。方法 门诊随机选择乳腺小叶增生症患者治疗组 2 88例 ,用他莫昔芬 10mg ,每日 2次 ,半月复诊一次 ,待症状缓解后改 10mg每日维持 ,根据临床分型用药 1～ 3个月。对照组 15 0例 ,用甲基睾丸素10mg每日 2次 ,维持时间相同。结果 他莫昔芬治疗组治愈率 45 5 % ,显效率 3 9 9% ,有效率 12 2 % ,无效率 2 4% ,总有效率为97 6%。对照组总有效率为 88% ,两组之间有显著差异 (P <0 0 5 ) ,未见不可逆副作用。结论 他莫昔芬治疗乳腺小叶增生症具有疗效确切 ,副作用小 ,服药方便等优点 。
Objective To study the clinical effect of tamoxifen on the treatment of breast cystic hyperplasia.Methods 288 cases of breast cystic hyperplasia were entered randomly as experimental group,it was given tamoxifen 10mg～20mg Bid for 1～3 months;and control group,was given methyltestosterone l0mg Bid,the clinical effect of the two groups was compared.Results In experimental group,the cure rate was 45 5%(131/288),the obviously effective rate was 39 9%(115/288),the effective rate was 12 2%(35/288),and the inffective rate was 2 4%(7/288),the total efficiency was 97 6%(281/288),while the total efficiency in control group was 88%(132/150).There was significant difference in the two groups(P<0 05).Conclusions The tamoxifen applied to treat the cystic hyperplasia of breast is effectiveness and less side effect.
出处
《中国医师杂志》
CAS
2003年第2期200-201,共2页
Journal of Chinese Physician
