摘要
目的 :探讨猪肺磷脂注射液治疗新生儿呼吸窘迫综合征 (NRDS)的临床疗效。方法 :NRDS患儿 47例 ,分为治疗组 2 3例 ,对照组 2 4例。两组按常规给予保暖、抗感染、静脉补液、保持电解质及酸碱平衡等处理。治疗组加用猪肺磷脂注射液 10 0mg·kg 1 气管内滴入。观察两组患儿的临床表现、动脉血气、呼吸机参数、X线胸片等指标。结果 :治疗组给药后缺氧及呼吸困难症状即刻改善 ,用药 2h动脉血气分析已明显好转 ,呼吸机参数下调。与对照组相比 ,治疗组2 4h动脉血气恢复迅速 ,呼吸机参数中吸入氧浓度 (FiO2 )明显低于对照组 (P <0 .0 1) ,但两组吸气峰压 (PIP)、呼气末压(PEEP)差别不大。同时治疗组在肺部病变改善、机械通气、氧疗时间、病程及预后方面都优于对照组。结论 :猪肺磷脂注射液对NRDS疗效确切 ,能有效改善氧合功能 ,缩短机械通气。
Objective:To investigate the clinical therapeutic effectiveness of porcine modified natural surfactant in the treatment of neonatal respiratory distress syndrome (NRDS). Methods:47 newborns with respiratory distress syndrome (RDS) were divided into two groups, with 23 in the treatment group and 24 in the control group. Patients of both groups were subjected to routine treatments including heat preseration, anti infection, intravenous fluid administration and maintenance of electrolyte and acid base balance. Besides, patients of the treatment group were given each two daily doses of 100 mg·kg 1 of porcine natural surfactant administered by intratracheal instillation. Clinical manifestations, arterial blood gases, parameters of artificial ventilation and changes in chest roentgenograms of the patients in both groups were kept under observation. Results:Hypoxemia and dyspnea in patients of the treatment group were rapidly relieved after administration of the porcine natural surfactant. There was a remarkable improvement in arterial blood gases and parameters of artificial ventilation within 2 h after the medication. The condition of patients of the treatment group was significantly better than that of the control group with respect to arterial blood gases and FiO 2 24 h after the medication( P <0.01). However, differences were insignificant between the two groups in the case of PIP or PEEP. Moreover, better results were noted in patients of the treatment group with regard to chest roentgenograms, duration of mechanical ventilation and oxygen therapy, as well as clinical course and prognosis. Conclusion:Porcine natural surfactant was shown to have a definite therapeutic effect in the treatment of NRDS by leading to rapid improvement in oxygenation, shortened duration of ventilation support, oxygen therapy and clinical course.
出处
《医药导报》
CAS
2003年第4期248-251,共4页
Herald of Medicine
