摘要
[目的]探讨乌梅丸治疗溃疡性结肠炎时病变结肠粘膜局部形态学变化,为中医药治疗溃疡性结肠炎提供理论依据。[方法]将40只大鼠随机分为正常对照组、模型组、柳氮磺胺吡啶(SASP)组和乌梅丸组4组,每组10只。除正常对照组外,其余3组均采用免疫加局部刺激的方法复制大鼠溃疡性结肠炎模型;柳氮磺胺吡啶组及乌梅丸组分别灌胃给柳氮磺胺吡啶(80 g/L SASP 10 mL/kg,每日1次)和乌梅丸小煎剂(每mL含生药2 g,14.3 mL/kg,每日1次);治疗结束后分别在光镜与电镜下观察各组病变结肠粘膜局部形态学变化。[结果]病理切片及超微病理结构观察显示,经乌梅丸治疗后渍疡性结肠炎大鼠病变结肠粘膜明显修复好转,其改善程度优于柳氮磺胺吡啶。[结论]乌梅丸治疗渍疡性结肠炎有较好的疗效。
[Objective] To observe the effect of Wumei Wan on histological features of colic mucosa of rats with uleera-tive colitis. [ Methods ] Forty rats were randomly allocated to normal control group ( Group A), model group ( Group B), salicylazosulfapyridine group (Group C) and Wumei Wan group (Group D). Ulcerative colitis models were established by immune method combined with local stimulation. After gastric infusion treatment, the histological features of colic mucosa of rats were observed under light microscope and transmission electron microscope. [Results] The results of pathological slices showed histological feature of colic mucosa in Wumei Wan group was much improved as compared with Group C. [Conclusion] Wumei Wan has a certain effect in treating ulcerative colitis.
出处
《广州中医药大学学报》
CAS
2003年第1期59-62,共4页
Journal of Guangzhou University of Traditional Chinese Medicine
关键词
乌梅丸
治疗应用
溃疡性结肠炎
中药疗法
病理学
WUMEIWAN/ther. use
ULCEMTIVE COLITIS/TCD therapy
ULCERATIVE COLITIS/pathology
