摘要
目的 :探讨以阳性症状为主 (P组 )和以阴性症状为主 (N组 )精神分裂症患者IL -1β ,IL -2 ,IL -6水平在治疗前后与正常对照者的差异。方法 :利用放射免疫方法测定血清中的IL -1β ,IL -2 ,IL -6水平。结果 :患者组与对照组比较 ,IL -2血清水平在治疗前明显低于对照组 (P <0 0 1)。P组患者IL -1β血清水平在治疗后高于治疗前 (P <0 0 5 )。P组与N组之间比较 ,治疗后IL -6水平呈现显著性差异 (P <0 0 5 )。未发现PANSS量表阳性症状得分 (P分 )和阴性症状得分 (N分 )与白介素水平的相关关系。未发现在患者组及对照组内部IL -1β、IL -2、IL -6之间的相关性。 结论 :精神分裂症患者与正常对照者相比血清白介素水平存在显著性差异。不同症状类型在治疗前后白介素水平改变的趋势不同。抗精神病药物对某些白介素水平有影响。
Objective: To study the treatment response of serum IL (interleukin) in type I and type II schizophrenia Method: 40 patients with first episode schizophrenia and 20 health control were collected Serum levels of IL-1β, IL-2 and IL-6 of both groups were measured by radioimmunoassay, in patient group before and after treatment Result: Before treatment, patients had lower level of IL-2 than control After treatment, patients with type I schizophrenia had higher level of IL-1β than before, they had also lower level of IL-6 than patients with type II schizophrenia did No correlation was found between P score or N score of PANSS and IL levels No association was found among different interleukins in both patient and control groups Conclusion: Patients with schizophrenia have lower IL-2 than normal Antipsychotics have some influence on interleukins, having different response with different type of schizophrenia
出处
《中国心理卫生杂志》
CSSCI
CSCD
北大核心
2003年第3期203-205,209,共4页
Chinese Mental Health Journal
