摘要
目的 探讨甲状腺局部注射免疫抑制剂地塞米松 (Dex)、环磷酰胺 (CTX)、环孢素A(CysA)、生长抑素类似物奥曲肽及无水乙醇联合应用治疗甲状腺功能亢进 (甲亢 )的疗效及安全性。方法 采用随机单盲法将 310 0例甲状腺功能亢进患者分为 5组 :A组 :Dex局部注射 ;B组 :Dex、CTX和CysA局部注射 ;C组 :奥曲肽局部注射 ;D组 :Dex、CTX、CysA和奥曲肽局部注射 ;E组 :Dex、CTX、CysA、奥曲肽和无水乙醇局部注射。局部治疗每周 1次 ,连续 3个月 ;然后每 2周 1次 ,共 4次 ;再改为每月 1次 ,共 2个月 ,观察甲状腺体积和功能、肝、肾功能及血、尿常规改变。结果 免疫抑制剂等药物局部治疗均可使甲状腺体积明显缩小 ,以E组最显著 ,治疗过程中肝、肾功能及血、尿常规无明显改变。
Objective To investigate the efficacy and safety of localized intra throid injection of dexamethasone(Dex), cyclophosphamide(CTX),cyclosporin A (CysA),sandostatin,ethanol in treatment of hyperthyroidism. Methods 3 100 patients with Graves' disease were randomly divided into 5 groups:① treated with Dex;②treated with Dex,CTX and CysA;③treated with sandostatin;④treated with Dex ,CTX,CysA and sandostatin;⑤treated with Dex ,CTX,CysA ,sandostatin and ethanol . Immunosuppressive agents were injected locally once a week for 3 months, then once for two months and once a month for 2 months. The changes of the thyroid volume, plasma T3 and T4 level, liver and kidney functions and blood routine were examined. Results Regression of enlargement of thyroid was obtained significantly after the local treatment, especially in group 5. The liver and kidney functions with, blood routine showed no change. Conclusion The localized intrathyroid injection of immunosuppressive agents is safe and effective in the treatment of Graves' disease.
出处
《上海医学》
CAS
CSCD
北大核心
2003年第1期18-20,共3页
Shanghai Medical Journal
