摘要
目的了解肝硬变大鼠和病人肝组织中 H_1和 H_2受体的变化。方法光学放射自显影术。结果大鼠肝组织受体密度(每1000μm^2银粒计数)正常/肝硬化 H_1受体:肝细胞346±32/117±18(P<0.01);肝静脉277±18/27±5(P<0.01)。肝动脉31±7/12±3(P<0.05);门静脉25±11/16±4(P<0.05);H_2受体:肝细胞289±21/168±24(P<0.01);肝动脉235±29/154±25(P<0.05);门静脉230±28/148±18(P<0.05);肝静脉261±36/101±18(P<0.01)。病人对照组/肝硬化 H_1受体:肝细胞69±19/63±15(P>0.05);肝动脉41±7/35±5(P>0.05);门静脉39±5/34±7(P>0.05);肝静脉36±8/35±5(P>0.05)。H_2受体:肝细胞512±38/168±23(P<0.01);肝动脉175±26/56±17(P<0.01);门静脉166±18/52±15(P<0.01);肝静脉313±52/239±41(P<0.01)。结论大鼠以 H_1受体占优势,人以 H_2受体为主;肝硬化大鼠及病人肝组织的 H_1、H_2受体明显低于对照组。
Objective To investigate the density of H_1 and H_2 receptors in hepatic tissues of cirrhotic rats and pa- tients with portal hypertension.Methods Using light autoradiography.Results The density of H_1 and H_2 re- ceptors in hepatic tissues (per 1000μcm^2) in rats (normal/cirrhosis):H_1 receptors 346±32/117±18 for hep- atocytes(HC,P<0.01),277±18/27±5 for hepatic venule walls (HV,P<0.01),31±7/12±3 for intrahep- tic artery walls(HA,P<0.05),and 25±11/16±4 for intrahepatic portal venous walls(PV,P<0.05);H_2 re- ceptors289±21/168±24 for HC(P<0.01),235±29/154±25 for HA(P<0.05),230±28/148±18 for PV (P<0.05),and 261±36/141±18 for HV(P<0.01);The density of H_1 and H_2 receptors on hepatic tissues in patients(control/cirrhosis)H_1 receptors 69±19/63±15 for HC(P>0.05),41±7/35±5 for HA(P> 0.05),39±5/34±7 for PV(P>0.05),and 36±8/35±5 for HV(P>0.05);H_2 receptors 512±38/168± 23 for HC(P<0.01),175±26/56±17 for HA(P<0.01),166±18/52±15 for PV(P<0.01),and 313± 52/239±41 for HV(P<0.01).Conclusion The density of H_1 and H_2 receptors in all of the hepatic tissues are significantly lower in cirrhotic rats and cirrhotic patients than in normal rats and control patients.
出处
《中华普通外科杂志》
CSCD
1998年第2期105-107,共3页
Chinese Journal of General Surgery
