摘要
目的 :观察急性冠状动脉综合征 (ACS)发病时炎性趋化因子的作用 ,探讨ACS发病机制。方法 :选取ACS患者 80例 ,其中急性心肌梗死 (AMI) 4 0例 ,不稳定型心绞痛 (UAP) 4 0例。ACS患者经治疗 4个月后进行随访。同时选取正常对照 4 0例。采用酶联免疫法测定上述病例和对照者血清中的巨噬细胞趋化蛋白 1(MCP 1)、白细胞介素 8(IL 8)水平 ,并进行统计学分析。结果 :AMI组、UAP组MCP 1显著高于对照组 ,并在随访时明显降低 ,而IL 8水平无明显差异。结论 :外周血中MCP 1水平可以作为诊断和预测ACS发生的敏感指标 ,并可以反映病情的稳定情况 。
Objective:To study the serum levels of certain inflammatory chemoattractants and its significance in acute coronary syndrome (ACS).Methods:The study population included 40 patients with acute myocardial infarction (AMI) and 40 patients with unstable angine pectons (UAP). 60 patients accepted a follow up 4 months. At the same time, we selected 40 controls from people who attended a routine health check.Serum levels of MCP 1?IL 8 were measured by means of ELISA.Results:Serum levels of MCP 1 were significantly higher in the ACS group than those in the control group, and became significantly lower at the fourth month after treatment, while the lerel of IL 8 showed no significant difference after freatment. Conclusion:Serum levels of MCP 1 may have certain diagnostic value for ACS, and can be a useful maker reflecting the an unstable stable of the disease.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2003年第2期87-89,共3页
Journal of Clinical Cardiology
