摘要
目的 :探讨原发性高血压患者血清胰岛素样生长因子Ⅱ (IGFⅡ )和肾上腺髓质素 (ADM)变化及其临床意义。方法 :用放射免疫分析测定了 6 2例原发性高血压 (EH)患者和 4 0例非高血压患者的血清IGFⅡ和ADM水平 ,并进行对照统计分析。结果 :EH组血清IGFⅡ和ADM水平均显著高于对照组 (p <0 0 1) ,相互间呈显著正相关 (p <0 0 5 ) ,且均与平均动脉压成显著正相关 (p<0 0 5 ) ,与体重指数无相关性意义。在Ⅰ、Ⅱ、Ⅲ期组间 ,血清ADM水平依次递增 (方差F检验 ,p <0 0 5 ) ,且Ⅲ期组显著高于Ⅰ期组 (p <0 0 1) ,伴心脑肾并发症组血清ADM水平也显著高于无并发症组 (p <0 0 5 ) ;血清IGFⅡ水平则无统计学意义。结论 :EH患者血清IGFⅡ和ADM水平显著升高 ,相互间成正相关 ,且均与平均动脉压成正相关 ,随着病情进展 ,ADM有进一步升高趋势 。
Objective To investigate the changes of serum levels of insulin-like growth factorⅡ (IGFⅡ) and adrenomedullin (AMD) in patients with essential hypertension. Methods Serum IGFⅡ and AMD levels were measured in 62 cases of hypertension and 40 controls with RIA. Results Serum IGFⅡ and ADM levels were significantly bigher in hypertensive patients than those in the controls ( t=4 454, p<0 01;t=3 992,p<0 01 ). The serum IGFⅡ level was significantly positively correlated to the serum ADM levels ( r=0 379,p <0 05) and both were significantly positively correlated to the mean arterial pressure ( r=0 346,r=0 353,p <0 05) but not with BMI. Serum ADM levels increased gradually as the disease progressed from stage Ⅰ to stage Ⅲ ( p <0 05) with levels in stage Ⅲ markedly higher than those in stage Ⅰ ( p <0 01). In EH patients with heart and/or brain and/or renal complications the serum ADM levels were significantly higher those in EH patients without complications ( t=2 050,p <0 05). Such differences did not exist in the case of IGFⅡ. Conclusion Serum IGFⅡ and ADM levels were increased markedly in hypertensive patients. These two factors were mutually positively correlated and both were positively correlated to mean arterial pressure. ADM levels increased gradually as the disease progerssing but IGFⅡ levels remained stable.
出处
《放射免疫学杂志》
CAS
2003年第1期19-21,共3页
Journal of Radioimmanology
