摘要
目的 测定血浆中透明质酸 (HA)与尿毒症和肾移植患者病情变化的关系。方法 采用竞争性酶联免疫吸附试验测定尿毒症组 (A组 )、肾移植组 (B组 )、正常对照组 (C组 )血浆HA水平 ,同时测定血清肌酐 (SCr)。结果 血清HA水平A组 ( 414 2 5± 2 0 8 6 5ng/ml)高于B组 [( 6 9 5 7±46 2 8)ng/ml]和C组 [( 6 0 85± 2 5 5 5 )ng/ml](P <0 0 5 ) ;B组和C组比较差异无显著意义 (P >0 0 5 ) ,与血肌酐呈正相关 (r=0 87)。同时A组患者血肌酐透析前后比较差异有显著意义 [分别是透前 ( 810 48± 2 14 72 ) μmol/L透后 ( 2 2 5 2 8± 16 6 32 ) μmol/L ,(P <0 0 5 ) ];而血浆HA透析前后无变化[分别是透前 ( 414 2 5± 15 7 83)ng/ml]透后 ( 40 2 34± 12 5 6 7)ng/ml,(P >0 0 5 ) ]。结论 血HA可作为评估尿毒症和肾移植患者病情变化的一个指标。
Objective To study and compare the serum levels of hyaluronate (HA) in patients of kidney transplantation. Methods A competitive ELISA was used to test HA in uremic group(A group),renal transplantation (B group),normal control group(C group). Results The serum HA levels were significantly higher in A group[(414.25±208.65)ng/ml] than B group[(69.57 ±46.28) ng/ml] and C group [(60.85 ±25.55) ng/ml] (P<0.05). There was no significantly high between B group and C group(P>0.05).Serum HA was positively correlated with creatinine level (r=0.87). No significant change of HA levels was found during hemodialysis[(414.25±157.83) ng/ml vs(402.34±125.67) ng/ml,(P>0.05)]. Conclusion The elevated serum HA is linked to a potential marker in kidney transplantation.
出处
《中华检验医学杂志》
CAS
CSCD
北大核心
2003年第1期28-30,共3页
Chinese Journal of Laboratory Medicine
关键词
尿毒症
血清
透明质酸
肾移植术
Hyaluronate acid
Kidney transplantation
Kidney failure Chronic
Renal dialysis
