摘要
用α-氨基甲基膦酸酯分别与N-氟乙酰基氨基酸酯和N-氯乙酰基胸酸酯进行亲核取代反应,合成了如下通式的新型含磷二肽,生物活性测定发现有的化合物具有较好的除草活性, (EtO)_2PCH_2NHCH_2CNHCHRCOOR’和(R^1O)_2PCH_2NHCH_2CNHCHRP(OPh)
It was reported in literature that phosphonodipeptides had significant biological activities. In order to look for new herbicides, a series of novel phosphonodipeptides have been prepared by the reaction of (PhO)2P(O)CH2NH2 or (EtO)2P(O)CH2NH2 with C1CH2CONHCHR COOR' and ClCH2CONHCHRP(O)(OPh)2 separately in the presence of triethylamine in benzene. The structures of all the compounds prepared were proved by 1H NMR, IR and MS. Their spectroscopic spectra and biological activities were discussed. It was found that some of them showed good herbicidal activity.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
1992年第5期611-616,共6页
Chemical Journal of Chinese Universities
基金
国家自然科学基金
关键词
Α-氨基膦酸酯
含磷二肽
除草活性
a-aminoalkyl phosphonate ester
Phosphonodipeptide
Herbicidal activity
