摘要
目的 了解我所就诊病人乃至全省 1996～ 2 0 0 1年结核分枝杆菌的耐药疫情、以及 MDR- TB菌株疫情。 方法 对来自全省 14个市 (州 )及所辖县 (区 )的涂阳肺结核病人的痰标本 ,进行结核培养 ,采用绝对浓度法进行 6种抗结核药物的耐药性测定分析。 结果 总耐药率由 1996～ 1997年的 73.0 %下降至 2 0 0 0～ 2 0 0 1年的 6 1.4 % ;MDR- TB菌株发生频率由 1996～ 1997年的 4 0 .7%下降至 2 0 0 0～ 2 0 0 1年的 36 .7%。原发性耐药率 (住院病人 )由 1996～ 1997年的 33.3%下降至 2 0 0 0～ 2 0 0 1年的 2 3.5 % ;MDR- TB菌株发生频率由 1996～ 1997年的 8.9%上升至 2 0 0 0～ 2 0 0 1年的 9.9%。获得性耐药率 (住院病人 )由 1996～ 1997年的 81.0 %下降至 2 0 0 0～ 2 0 0 1年的 79.1% ;MDR- TB菌株发生率由 1996～1997年的 4 8.0 %上升至 2 0 0 0～ 2 0 0 1年的 4 8.5 %。 结论 近 6年来 ,来自全省各地结核病病人结核分枝杆菌总耐药率和总 MDR- TB菌株发生率均呈下降趋势 ;原发性耐药率呈下降趋势 ;但获得性耐药率和 MDR-
Objective To investigate drug resistance of M.TB and MDR-TB in patients in our hospital and the whole province during the period of 1996 to 2001. Methods The sputum specimen of smear-positive pulmonary TB patients from 14 cities in Hunan Province was incubated, and all the strains were identified at the same time. Drug Resistance was tested with six kinds of antimycobacterium drugs by absolute concentration. Result The rate of total drug resistance and incidence of MDR-TB decreased to 61.4% and 36.7% respectively during 2000~2001. The rate of primary drug resistance decreased from 33.3%. in 1996~1997 to 23.5% in 2000~2001. Whereas the incidence of MDR-TB rose from 8.9% in 1996～1997 to 9.9% in 2000～2001. The rate of acquired drug resistance decreased to 79.1% during 2000~2001 while the incidence of MDR-TB rose 48.5% in 2000～2001. Conclusion In recent six years in Hunan province, the rate of total drug resistance( primary drug resistance )and the incidence of total MDR-TB showed a decreasing trend, but the frequency of acquired drug resistance and incidence of MDR-TB were still high.
出处
《实用预防医学》
CAS
2003年第1期53-55,共3页
Practical Preventive Medicine
