摘要
目的 探讨端粒酶活性和口腔鳞癌发生、发展的关系。方法 采用TRAP -PCR -ELISA法对 32例口腔鳞癌标本、1 5例癌旁组织和 1 0例正常口腔粘膜组织进行端粒酶活性检测和分析。结果 口腔鳞癌组织中端粒酶活性值显著高于癌旁组织和正常组织 (P <0 .0 5)。端粒酶在口腔鳞癌标本中阳性检出率 71 .87% ,显著高于癌旁组织和正常组织 (P <0 .0 1 ) ,且和鳞癌的病理分级及有无颈淋巴结转移密切相关。结论 端粒酶活性和口腔鳞癌的发生。
Objective To explore the relationship between telomerase activity and occurence and development of human oral mucosal squamous cell carcinoma(SCC).Methods 32 SCC,15 adjacent normal tissue and 10 normal oral tissue were examined for telomerase activity by TRAP-PCR-ELISA assay.Results The telomerase activity was significantly higher in SCC than that of adjacent tissue,and than that of normal tissue as well.24 of 50 the SCC specimens were positive for telomerase activity with a positive rate of 71.87 %.The positive rate for telomerase was colsely correlated with histopathological grading and lymph node metastasis of SCC.Conclusion Telomerase activity is colsely related to occurence and development of SCC.
出处
《现代口腔医学杂志》
CAS
CSCD
2003年第1期4-6,共3页
Journal of Modern Stomatology
关键词
口腔鳞癌
端粒酶
端粒
Oral squamous cell carcinoma Telomerase Telomere
