摘要
目的 :考察水溶性联合载体在增加难溶性药物的溶出速率上是否优于单一载体 ,并制备速释型固体分散体。方法 :分别用 PEG 60 0 0、泊洛沙姆 Poloxamer 1 88及二者不同比例联合做载体制备尼莫地平与载体比为 1∶ 4的固体分散体。 X射线衍射法观察尼莫地平在分散体中的分散状态 ,并通过体外溶出试验考察其溶出速率。结果 :X射线衍射固体分散体中尼莫地平一部分呈分子状态分散 ,另一部分呈微晶状态分散。体外溶出试验中分散体的溶出速率明显快于原料药及物理混合物。结论
Objective:To investigate whether the combined carrier is superior to the single carrier in improving dissolution of poorly insoluble water drug and prepare a fast released solid dispersion. Methods: Nimodipine solid dispersion were prepared with PEG6000, Poloxamer 188 as single carriers and combined carriers(which was made of different ratios between the two carriers), respectively. The ratio of nimodipine against carrier(s) in all solid dispersions was 1∶4.X ray power diffraction was used to study the state of nimodipine in the solid dispersions and the dissolution test was used to study the dissolution rate. Results:The results of X ray power diffraction showed that some nimodipine existed as molecular state and others existed as crystallite. Dissolution test in vitro indicated that the dissolution rates of solid dispersions were obviously faster than those of the pure drug and physical mixture. All solid dispersions with PEG6000 and Poloxamer 188 as combined carriers were obviously faster than NM PEG6000 solid dispersion ( P <0.01), but not all faster than NM Poloxamer 188 solid dispersion NM solid dispersion with Poloxamer 188 and PEG6000(1∶15) as combined carrier indicated a faster dissolution rate with t 50 equal to 4.45 min and less Poloxamer 188. Conclusion: The combined carrier is approximately superior to the single carrier in increasing dissolution of poorly insoluble water drug.
出处
《吉林大学学报（医学版）》
CAS
CSCD
北大核心
2003年第1期72-75,共4页
Journal of Jilin University：Medicine Edition
关键词
尼莫地平
固体分散体
X线衍射
体外溶出速率
nimodipine
solid dispersion
X ray diffraction
dissolution rate in vitro
