摘要
目的:探讨在新生儿HIE治疗中常规应用西咪替丁预防消化道出血的临床效果。方法:319例HIE患儿随机分为观察组162例,对照组157例,观察组在对照组治疗基础上加用西咪替丁8 mg/kg静脉滴注,2次/d,7 d为一疗程。结果:观察组发生消化道出血3例(1.86％),对照13例(8.28％),两组比较x2=6.92,P<0.05。结论:HIE治疗中常规加用西咪替丁能有效预防消化道出血的发生。
Objective: To explore the effect of cimetidine on preventing hemorrhage of digestive tract in the neonates with hypoxic ischemic encephalopathy (HIE). Methods: 319 neonates with HIE were randomly divided into the preventive group (n = 162) and the control group (n = 157). The control group was routinely treated. On the basis of routine treatment the preventive group took cimetidine 8 mg/kg, twice daily for 7 days. Results: There were 3 cases (1. 86% ) and 13 cases (8. 28% ) had the hemorrhage of digestive tract respetively in the preventive group and control group. There was a significant difference between the two groups (x2 = 6. 92, P < 0. 05). Conclusions: In the treatment of the HIE, routinely taking cimetidine will prevent the occurrence of hemorrhage of digetive tract significantly.
出处
《儿科药学杂志》
CAS
2003年第1期35-37,共3页
Journal of Pediatric Pharmacy
关键词
缺氧缺血性脑病
消化道出血
应激性溃疡
西咪替丁
预防
Hypoxic ischemic encephalopathy
Hemorrhage of digestive tract
Stress-related gastric injury
Cimetidine
Prevention
