摘要
目的 评价肿瘤标志物CA125、CA19.9、CA15-3在卵巢良恶性肿瘤的诊断价值,以提高CA125单独测定的敏感性与特异性。方法应用放射免疫方法测定了21例卵巢良性肿瘤及21例卵巢恶性肿瘤的血清CA125、CA19.9、CA15-3值并进行比较分析。结果 卵巢恶性肿瘤患者血清CA125、CA15-3含量显著高于良性肿瘤组(P<0.001),单独应用CA125诊断卵巢恶性肿瘤的准确性为78.57％,优于CA15-3和CA19.9。而以三项肿瘤标记物中的任意两项阳性为标记物诊断阳性时,准确性为85.71％,较CA125单独测定诊断卵巢良恶性肿瘤有较高的准确性。结论 CA125、CA15-3、CA19.9三项肿瘤标记物联合检测,以其中任意两项同时增高作为阳性标准,对提高卵巢良、恶性肿瘤诊断及鉴别诊断的准确性有一定意义。
Objective CA125,CA19.9 and CA15 - 3 are antigenic determinants associated with human ovarian carcinomas. Murine monoclonal antibodies have been raised against these determinants, to improve specificity and sensitivity of differentiating ovarian cancer from benign tumors. MethodsImmunoradionetric assays have been developed to monitor antigen levels in 21 women with ovarian cancer 21 with benign pelvic masses. Results The average content of tumor markers in ovarian cancer was higher than benign tumor (P<0.001),as a single assay. The accuracy of CA125 is 78.57% .But the accuracy of combination of CA125,CA19.9 and CA15 - 3 which two indices showed positive is 85.71 % .Conclusion Combined assaying CA125,CA19.9 and CA15 - 3 in which 2 indices showed positive was superior to using one marker for the diagnosis of ovarian cancer.
出处
《河南肿瘤学杂志》
2003年第1期12-13,共2页
Henan Journal of Oncology
