摘要
目的 探索冠心病急性心肌梗死和不稳定型心绞痛的早期实验室诊断方法。方法 分别采用免疫浊度法、酶速率法测定 60例冠心病 ( CHD)患者及 2 0例正常对照组 ( CP)的 C反应蛋白 ( CRP)、心肌肌钙蛋白 ( c Tn )、肌酸激酶 ( CK)及其同工酶 ( CK- MB)的阳性率。结果 CHD组患者的 CRP、 c Tn 、CK- MB和 CK的阳性率均明显高于 CP组 (均为 P<0 .0 5 )。CHD组又分为 3组 ,急性心肌梗死组 ( AMI) 2 0例、不稳定型心绞痛组 ( U A) 2 0例、稳定型心绞痛组 ( SA) 2 0例。AMI组患者的 CRP、c Tn 、CK- MB和 CK阳性率明显高于 SA组 (均为 P<0 .0 1) ;UA组 CRP和 c Tn 的阳性率明显高于 SA组 (均为 P<0 .0 1) ,但两组间 CK- MB和 CK的阳性率相比无明显差异 (均为P>0 .0 5 )。结论 CRP和 c Tn
Objective To investigate the early diagnosis of acute myocardiac infarction and unstable angina pectoris. Methods By using immuneturbidity test and enzyme for rapid quantification, C-reactive protein (CRP), cardiac troponin Ⅰ (cTnⅠ), creatine kinase isoenzyme MB(CK-MB)and creatine kinase(CK)were determined in 60 patients with coronary heart disease (CHD group) and 20 healthy volunteers (control group). Results The positive rate of CRP, cTnⅠ, CK-MB and CK in CHD group was significantly higher than in control group (P<0.05). The patients with CHD were divided into 3 groups: 20 cases of acute mycocardial infarction (AMI group), 20 cases of unstable angina pectoris (UA group) and 20 cases of stable angina pectoris (SA group). The positive rate of CRP, cTnⅠ, CK-MB and CK in the AMI group were significantly higher than in the SA group (P<0.01). The positive rate of CRP and cTnⅠ in the UA group were significantly higher than in the SA group (P<0.01), but there was no significant difference in the positive rate of CK-MB and CK between UA group and SA group. Conclusion There was a significant correlation between the evalation of CRP, cTnⅠ and the risk of recurrent coronary events.
出处
《华中科技大学学报（医学版）》
CAS
CSCD
北大核心
2003年第1期43-45,共3页
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
关键词
C反应蛋白
心肌肌钙蛋白I
肌酸激酶
冠心病
C-reactive protein
cardiac troponin Ⅰ
creatine kinase
coronary heart disease
