摘要
目的 探讨前列腺癌组织中上皮型钙粘附素 (E cadherin)表达及与PSA的关系。 方法 采用免疫组织化学染色法检测 5 6例前列腺癌组织标本E cadherin的表达 ,分析表达水平与总PSA(T PSA)、游离PSA(F PSA)及F/T值的关系。 结果 E cadherin正常表达 2 4例 ( 43 % ) ,异常表达3 2例 ( 5 7% ) ,E cadherin表达缺失与肿瘤恶性程度及分期呈正相关 (P <0 .0 1) ,与患者T PSA、F PSA无明显相关性 ,而与F/T值呈正相关 (P <0 .0 1)。 结论 E
Objective To investigate the expression of E-cadherin in prostate cancer and its relationship with PSA. Methods E-cadherin expression of 56 prostate cancer samples were studied by immunohistochemical stain and its expression level was analyzed with respect to T-PSA, F-PSA and F/T ratio. Results 24 patients (43%) were normal and 32 patients (57%) were aberrant in E-cadherin expression. E-cadherin was related significantly to the grade and stage of cancer and the changes of F/T ratio.There were no significant relationship between E-cadherin expression and T-PSA or F-PSA. Conclusions E-cadherin expression may act as a marker to the malignant degree and the prognosis of the prostate cancer.
出处
《中华泌尿外科杂志》
CAS
CSCD
北大核心
2003年第2期114-116,共3页
Chinese Journal of Urology
基金
国家自然科学基金资助项目 ( 3980 0 173)
国家教委留学回国人员科研启动基金资助项目
关键词
前列腺肿瘤
E钙粘附素
前列腺特异抗原
Prostatic neoplasms
Carcinoma
E-cadherin
Prostate specific antigen
