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生长素在2型糖尿病发病及控制中的意义初探 被引量：3

The Clinical Significance of Ghrelin in Type 2 Diabetes
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摘要 目的 :了解2型糖尿病患者生长素的变化 ,并探讨生长素在糖尿病发生和发展中的临床意义。方法 :利用放免法测定24例2型糖尿病患者及24例正常人血浆生长素、生长激素浓度 ,用氧化酶法测定血糖浓度。结果 :2型糖尿病患者血浆生长素水平 (141 8±25 4) μg/L明显高于正常对照组 (110 8±21 5) μg/L(P<0.05) ,生长激素水平 (3 2±0 7) μg/L明显高于正常对照组 (1 6±0 3) μg/L(P<0.05) ,血浆生长素水平与生长激素、血糖及体重指数呈正相关。结论 :2型糖尿病患者血浆生长素浓度增高 ,可能引起血浆生长激素增高 ,进而引起血糖增高 。 Objective:To study the clinical significance of the changes of Ghrelin in type 2 diabetic patients.Methods:The serum Ghrelin and growth hormone(GH)were measured using RIA in 24 type 2 diabetes and 24 normal people.Results:The plasma levels of Ghrelin and GH in type 2 diabetes were significantly higher than that in control group[(141 8±25 4)μg/L vs(110.8±21.5),(3 2±0 7)μg/L vs(1 6±0 3)μg/L,respectively,P<0.05)]. Ghrelin was positively related to GH,blood glucose(P<0.01),and body mass index(P<0.05).Conclusion:The level of plasma Ghrelin increased in type 2 diabetes,and might cause the increase of GH and blood glucose.Ghrelin may be related to the attack of type 2 diabetes.
作者 臧贵明 张昭馥 费宇行 王洪瑛 王春 曹悦鞍 张肇康 赵云涛
机构地区 海军总医院干三科 海军总医院心内科 美国PhoenixPharmaceuticalsins
出处 《天津医药》 CAS 北大核心 2003年第2期74-76,共3页 Tianjin Medical Journal
关键词 生长素 2型糖尿病 发病 控制 临床意义 diabetes mellitus,non_insulin_dependent ghrelin growth hormone
分类号 R587.1 [医药卫生—内分泌]
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参考文献8

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同被引文献38

  • 1管庆波,韩辉,董建军,蒋玲,赵文博,赵家军,王桂兰.胰岛素治疗对糖尿病大鼠学习记忆功能障碍及大脑皮层额叶和海马神经肽含量变化的影响(英文)[J].神经科学通报,2005,21(3):215-218. 被引量：6
  • 2马学毅,丁贵清,卜广和,等.现代糖尿病诊断治疗学[M].北京:人民军医出版社,2009:306.
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  • 6Tschanz JT, Corcoran C, Skoog I, et al. Dementia the leading predictor of death in a defined elderly popu- lation: The Cache County study [ J ]. Neurology, 2004, 62: 1156-1162.
  • 7Crane PK, Walker R, Hubbard RA, et al. Glucose Levels and Risk of Dementia [ J ]. N Engl J Med, 2013, 369: 540-548.
  • 8Leibson CL, Rocca WA, Hanson VA, et al. The risk of dementia among persons with diabetes mellitus: a population- based cohort study [ J]. Ann N Y Acad Sci, 1997, 826 (26): 422-427.
  • 9Luchsinger JA, Tang MX, Stern Y, et al. Diabetes mellitus and risk of Alzheimer' s disease and dementia with stroke in a multiethnic cohort [ J]. Am J Epide- miol, 2001, 154 (7): 635-641.
  • 10Brazeau P, Vale W, Burgus R, et al. Hypothalamic polypeptide that inhibits the secretion of immunoreac- tive pituitary growth hormone [ J]. Science, 1973, 179 (4068): 77-79.

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天津医药
2003年 第2期

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