2Masuda J,Omagari K,Matsuo I,et al. Changes in titers of antirnitochondrial and antinuclear antibodies during the course of primary biliary cirrhosis[ J]. J Gastroenterol Hepatol,2001,16: 239 - 243.
4Faubion W, Guicciardi M, Miyoshi H, et al. Toxic bile salts induce rodent hepatocyte apoptosis via direct activation of Fas [ J ]. J Clin Invest, 1999, 103 ( 1 ) : 137 - 145.
5Benz C, Angermuller S, Tox U, et al. Effect of tanroursodeoxycholic acid on bile - acid - induced apoptosis and cytolysis in rat hepatocytes[ J]. J Hepatol, 1998, 28 ( 1 ) : 99 - 106.
6Qiao L, Yacoub A, Studer E, et al. Inhibition of the MAPK and PI3K pathways enhances UCDA -induced apoptosis in primary rodent hepatOcytes [ J ]. Hepatology, 2002,35 ( 3 ) : 779 - 789.
7Rodrigues CM, Steer CJ. The therapeutic effects of ursodeoxycholic acid as an anti - apoptotic agent [ J ]. Expert Opin Investig Drugs. 2001,10(7) : 1243 - 53.
8Setchell KDR, Rodrigues CMP, Clerici C, et al. Bile acid concentrations in human and rat liver tissue and in hepatocyte nuclei [ J ]. Gastroenterology, 1997,112 (2) : 226 - 35.
9Guldotana S, Zimmer G, Immhol M, et al. Molecular aspects of membrance stabilization by ursodeoxycholate [ J ]. Gastroenterology, 1993, 104(6): 1736 -44.
10Alpini G, Baiochchi L, Glaser S, et al. Ursodeoxycholate and tauroursodeoxycholate inhibit cholangiocyte growth and secretion of BDL rats through activation of PKC alpha [ J ]. Hepatology, 2002, 35 (5): 1041 -1052.