摘要
目的 旨在探索高氧液体治疗缺血缺氧性疾病的部分基础药理特性 ,为临床应用提供可靠的理论依据。方法 用光量子溶氧技术将O2 高浓度的溶解在复方林格氏液体中 ,称为高氧液体或晶体携O2 液 ,并探讨高氧液体对静脉血氧分压、红细胞脆性和失血性休克的PaO2 、SaO2 与血液粘滞度等指标的影响。结果 高氧液体的LD50 、红细胞脆性和热原质试验与溶液氧前林格比较无改变 (P >0 0 5 )。溶氧后高氧液体的氧分压由 2 1kPa上升到 90 - 10 0kPa ,能容量依赖性的提高静脉血氧分压和氧饱和度 ,能明显提高急性失血性休克家兔的PaO2 和SaO2 ,并降低血液粘滞度。结论 高氧液体不改变基液的基本特性 ,符合人体输注的各项要求 。
AIM To understand the basic pharmacological peculiarity of hyperoxygenic liquid on the treatment of hypoxic and hypoxemia diseases. METHOD The dissolvent oxegene's technology of ultraviolet ray and the basic pharmacological research technique were employed RESULTS The erythrocyte brittleness and LD 50 and heat source test of hyperoxegnic liquid are not so changeable as compound acetate sodium( P >0 05) What was formerly 21 kPa of compound acetate sodium liquid PO 2 has now become the 90～100 kPa of hyperoxegenic liquid The hyperoxenic liquid could improve P v P 2 and S V O 2 as quickly and induce obvious blood viscosity CONCLUSION The chemical composition and basic specific property of compound acetate sodium could be not altered in hyperoxegenic liquid which have obviously the treatment effects on hypoxic and hypoxemia diseases
出处
《中国药理学通报》
CAS
CSCD
北大核心
2002年第5期560-562,共3页
Chinese Pharmacological Bulletin
基金
国家骨干教师资助课题
陕西省自然科学基金资助课题 No99SM 3 9
