摘要
采用了第 1、2、4号全染色体探针 ,以荧光原位杂交 (FISH)技术 ,分析了广东天然高本底辐射地区 (HBRA) 5名儿童和 13名老年男性以及对照地区 (CA) 6名儿童和 11名老年男性淋巴细胞染色体的易位率。与老年人相比 ,儿童染色体的易位率低 ,且变异小 ;而在老年人中个体之间的易位率波动很大。高本底辐射地区居民染色体易位率与对照地区居民相应值比较无显著性差异。没有观察到高本底地区居民和对照地区居民在染色体稳定性畸变 (易位 )频率方面存在差异 ,这一研究结果与流行病学研究结果是一致的。长期的流行病学群组调查没有发现高本底地区存在与高本底辐射有关的癌症危险度增加。
Chromosome translocations were analyzed by chromosome painting techniques using No.1, 2 and 4 whole chromosome painting probes to examine the effect of high-level natural radiation on the frequencies of chromosome translocations in human peripheral lymphocytes. The subjects were 5 children and 13 old men from the high background radiation area and 6 children and 11 old men from the control area. Children had lesser translocations and smaller variation compared with the old men. The frequency of translocations among the old subjects varied widely from person to person. No difference of the frequency of chromosome translocations between high background radiation area and control area. No effect of high-level natural background radiation on the frequencies of stable chromosome translocation was detected.
出处
《辐射研究与辐射工艺学报》
CAS
CSCD
北大核心
2002年第4期260-264,共5页
Journal of Radiation Research and Radiation Processing
基金
中日合作研究经费 (卫国合双字 95第 0 30 8号 )资助
关键词
高本底辐射
人体淋巴细胞
染色体彩涂
染色体易位
辐射健康效应
High background radiation, Human lymphocyte, Chromosome painting, Chromosome translocation, Health effect of radiation
