摘要
本文报道用微核胞质分裂阻断法研究BSO(丁胱亚磺亚酰胺,Buthione Sulfoximine)对细胞微核率的影响。研究结果表明BSO对正常人外周血淋巴细胞、BCa-P 37人乳腺癌细胞、中国仓鼠V79细胞和中国仓鼠CHO细胞在用药浓度0.1-2mmol/L情况下,微核发生率与未用药组无显著性差异,在^(60)COγ射线照射下,细胞的微核发生率与辐射剂量呈线性关系,当照射合并BSO时,微核发生率明显增加,表示BSO对细胞具有增加电离辐射的损伤作用。
The effects of BSO (buthionine sulfoximine), a potent radiosensitizing
and chernosensitizing chemical, on the incidence of micronuclei in four different cell
1ines have been studied using the cytokinesis-block (CB) method. The number of mic-
ronuclei in cultured human peripheral lymphocytes, Chinese hamster cells and human
breast cancer cells were not affected by 0.1-2 mmol/L BSO treatment alone. Howe-
ver, significant increase in the incidence of micronuclei in these cells could be detected
when BSO was used in combination with γ-irradiation. Linear relationship between the
incidence of micronuclei and the radiation dese was observed.
出处
《辐射研究与辐射工艺学报》
CAS
CSCD
北大核心
1992年第1期51-53,共3页
Journal of Radiation Research and Radiation Processing
基金
国家自然科学基金
关键词
细胞微核率
增敏化合物
放射损伤
Incidence of micronuclei
Buthionine sulfoximine(BSO)
Radiation
Cytokinesis-block method
