摘要
本实验观察了低剂量 X 射线整体和离体照射后对小鼠脾淋巴细胞丝裂原反应的影响。结果表明,X 射线全身照射后小鼠脾脏 T、B 淋巴细胞对刀豆蛋白-A(Con A)和细菌脂多糖(LPS)的反应较对照组增强,尤以75 mGy 组最为明显。在离体照射后,脾淋巴细胞对 Con A 的反应未见明显改变,而对 LPS 反应则低于对照组。提示低剂量 X 射线照射可刺激 T 细胞反应增强。
The changes of proliferative response of splenocytes to mitogens were studied in mice afterlow dose X-irradiation in vivo and in vitro.It was found that both the proliferative responses ofsplenocytes to Con A and to LPS increased after whole body X-irradiation,being more marked at theradiation dose of 75 mGy.No significant change of the proliferative response of splenoeytes to Con Awas found after X-irradiation in vitro.However,the response of splenocytes to LPS showed a dose-dependent depression after in vitro radiation in the dose range from 25 to 250 mGy.The cause of thedifference between in vivo and in vitro studies was discussed.
出处
《辐射防护》
CAS
CSCD
北大核心
1992年第4期282-284,281,共4页
Radiation Protection
基金
国家自然科学基金资助课题
关键词
淋巴细胞
X辐射
辐射生物效应
In Vivo Irradiation
In Vitro Irradiation
Low Dose
X-Irradiation
Splenoeytes
Con A
LPS
