摘要
目的 对抽样人群脑血管血液动力学指标 (CVHI)检测和分析 ,研究中国正常人CVHI的参考值范围。方法 在进行中风预防干预前瞻性研究的同时 ,从东北、华北、西南、西北、华东、华南等六大行政区 ,2 6个城市筛选了无脑卒中病史和危险因素暴露史的正常对照者 1 4 4 80名 (3～ 92岁 ) ,进行CVHI指标检测。将检测结果按照年龄、性别、地区和左右侧检测部位分组 ,用正态分布法计算单侧 95 %参考值范围。结果 1 0对检测指标的 95 %参考值范围的分布特点是 :颈总动脉血流速度的最大值 (Vmax)、最小值 (Vmin)、平均值 (Vmean)的下限随着年龄的增长呈下降趋势 ,而脑血管外周阻力 (RV)、特性阻抗 (Zcv)、脉搏波波速 (WV)、动态阻力 (DR)、临界压 (CP)等指标的上限则随着年龄的增长呈上升趋势 ,血流量 (Qmean)和压力差 (DP)无明显的年龄升降趋势 ;男性的Qmean、Vmax的下限和RV、DR、CP、DP的上限高于女性 ,而WV和Zcv的上限低于女性 ;左侧的Qmean、Vmean、Vmax、Vmin上限和WV、Zcv、CP的下限高于右侧 ,而RV、DR和DP的上限低于右侧 ;不同地区间各指标的分布差异无显著性。结论 不同年龄、性别和左右检测部位CVHI检测指标的单侧 95 %参考值范围有明显差异 ,参考值范围应分组计算。
Objective To study the reference range of cerebrovascular hemodynamics indexes (CVHI) in a sampling population. Methods Fourteen thousand, four hundred and eighty participants without history of stroke or exposure to risk factors were screened from 26 cities in Northeast China, North China, East China, Northwest China, South China, and Southwest China in the prospective study on stroke intervention. CVHI were checked and 95% confidence intervals were calculated using normal distribution methods, which were grouped by age, sex, area, and check positions. Results Characteristics of CVHI 95% confidence intervals showed that low limit of carotid blood velocity as V max , V min , V mean decreased, but upper limit of cerebral RV, Zcv, WV, DR and CP increased with the increase of age. However, Q mean and DP did not show significant trends of age difference. Low limit of Q mean , V max and upper limit of RV, DR, CP and DP in males were higher than that in females while upper limit of WV and Zcv in females were higher than that in males. Left carotid low limit of Q mean , V mean , V max , V min , and upper limit of WV, Zcv and CP were higher than that of the right but upper limit of RV, DR and DP were lower than that of the right. There were no obvious differences between areas. Conclusion Obvious differences of CVHI 95% confidence intervals ranges were found between age groups, sex, and checking positions, respectively, suggesting that the reference ranges of CVHI to be estimated by every subgroup.
出处
《中华流行病学杂志》
CAS
CSCD
北大核心
2003年第2期98-101,共4页
Chinese Journal of Epidemiology
基金
国家自然科学基金资助项目 ( 39370 6 12 )
上海市科技发展基金资助项目 ( 934 1130 6 0
94 4912 0 14 )
