摘要
目的总结黑斑息肉病及其合并恶变的临床特征,提高其诊断和治疗的水平。方法对1982年2月至2001年8月间收治的28例黑斑息肉病(其中5例并发消化道恶性肿瘤)患者的临床资料进行回顾性分析。结果本组13例(46.4%)有明确的家族史。皮肤黏膜色素沉着(100%)、腹痛(78.6%)、便血(57.1%)为主要临床表现;恶变(17.9%)、肠梗阻(67.9%)、消化道出血(57.1%)为主要并发症;恶变患者确诊时的平均年龄30岁。22例予内镜高频电凝切除术,10例予息肉切除,恶变的5例予肠切除。恶变者的病理组织学分型均为黏液腺癌。结论黑斑息肉病患者是典型的恶性肿瘤高发人群,发病年龄轻,病理分化程度较差,故应定期复查内镜。内镜高频电凝切除术是提高黑斑息肉病远期疗效的有效方法。
Objective To evaluate the clinical features of Peutz Jeghers syndrome and its canceration,and improve its diagnosis and treatment.Methods Clinical data of 28 cases with Peutz Jeghers syndrome including 5 cases with canceration from Feb 1982 to Aug 2001 were analyzed retrospectively. Results Nearly half of the patients(13/28) had an obvious family history. Abdominal pain,hematochezia,and pigmentation of skin and mucosa were main manifestations,occurring in 22, 16 and all patients respectively. Canceration,intestinal obstruction and alimentary hemorrhage were major complications. The mean age at diagnosis of canceration was 30 years old.22 patients underwent high frequency electroresection,10 polypectomy,and 5 cases with canceration did enterectomy.Conclusions Patients with Peutz Jeghers syndrome are at high risk for canceration with early onset and poor differentiation. Endoscope should be performed regularly and high frequency electroresection is an effective method to improve the long term outcome.
出处
《中华胃肠外科杂志》
CAS
2003年第1期27-28,共2页
Chinese Journal of Gastrointestinal Surgery
