摘要
目的 观察高通量血液透析对慢性肾衰竭尿毒症患者血浆瘦素 (leptin)水平及生活质量的影响。方法 以 30例维持性血透患者为治疗组 ,给予聚砜膜高通量血透每周 2次 ,每次 4.5h治疗 ,分别观察其透析前、后、30天、90天血浆瘦素、CRP、HGB、Bun、Cr浓度变化及体重、血压、食欲、精神状态、贫血的改善情况 ,并与正常对照组 (n =30 )进行对照分析。结果 治疗组透析前血浆瘦素浓度比正常对照组明显升高 (t=13 .45 ,P <0 .0 1) ,透析后比透析前明显降低 (t=9.5 4,P <0 .0 1)。透后 30天血浆瘦素、CRP、Bun、Cr浓度保持较低水平 ,与透析前比较差异有高度显著性 (t分别为6 .5 0 ,5 .2 4,13 .80 ,4.15 ,P均 <0 .0 1)。透后 90天血浆瘦素、CRP浓度上升至透前水平 (t分别为 0 .97,0 .45 ,P均 >0 .0 5 ) ,Bun、Cr浓度保持较低水平 ,贫血、体重、血压、食欲、精神状态均有不同程度改善。结论 聚砜膜高通量透析器对血清瘦素有清除作用 ,并能改善预后 ,提高生活质量。
Objective To study the effects of high-flow hemodialysis on plasma leptin levels and life quality in patients with urinaemia of kidney failure.Methods 30 patients received continuous hemodialysis were divided as the therapeutic group. The course of treatment with high-flow hemodialysis was twice every week, 4.5 hours every times. The changes of plasma leptin levels, CRP, HGB, Bun, Cr concentration before, after, 30 days after, 90 days after hemodialysis were all observed, so were the improved condition of weight, blood pressure, appetite, spirit and anemia of the patients. All the above mentioned indexes in the therapeutic group were compared to those in the control group (n=30).Results The plasma leptin levels before hemodialysis in the therapeutic group were significantly higher than those in the control group (t=13.45, P<0.01), they decreased significantly after hemodialysis than those before hemodialysis (t=9.54, P<0.01). 30 days after hemodialysis, the plasma leptin, CRP, Bun and Cr concentration remained in lower levels, in comparison to those before hemodialysis, the differences were significant, t=6.50, 5.24, 13.80, 4.15, P<0.01. 90 days after hemodialysis, levels of plasma leptin and CRP concentration increased to the levels before hemodialysis (t=0.97, 0.45, P>0.05). Bun, Cr concentration remained lower levels. The condition of anemia, weight, blood pressure, appetite and spirit had been improved at different degrees.Conclusions Polysulfone membrane High-flow hemodialyzers could remove serum leptin and improve prognosis condition and life quality.
出处
《右江民族医学院学报》
2003年第1期25-27,共3页
Journal of Youjiang Medical University for Nationalities
