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TSHR与自身免疫性甲状腺疾病关系的研究进展 被引量：7

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摘要 自身免疫性甲状腺疾病 (AITD)是一组器官特异性自身免疫性疾病 ,促甲状腺素受体 (TSHR)是其重要的自身抗原 ,在遗传和环境因素共同作用下 ,可以诱导机体产生特异性抗体 ,即TSHR抗体 (TRAb) ,它介导损伤性免疫应答。
作者 段薇 杜建玲 李昌臣
机构地区 大连医科大学附属四院 大连医科大学附属第一医院内分泌科
出处 《国外医学（内分泌学分册）》 2003年第1期40-42,共3页 Foreign Medical Sciences(Section of Endocrinology)
关键词 促甲状腺素受体 甲状腺疾病 自身免疫性 发病机制 基因突变
分类号 R581.02 [医药卫生—内分泌]
  • 相关文献

参考文献10

  • 1Tomer Y,Barbesino G,Keddache M,et al.Mapping of a major susceptibility locus for Graves’disease (GD-1) to chromosome 14q31[].The Journal of Clinical Endocrinology.1997
  • 2Sunthornthepvarakul T,Kitvitayasak S,Ngowngarmaratana S,et al.Lack of association between a polymorphism of human thyrotropin receptor gene and autoimmune thyroid disease[].Journal of the Medical Association of Thailand.1999
  • 3Akamizu T,Moriyama K,Miura M,et al.Characterization of recombinant monoclonal antithyrotropin receptor antibodies (TRAbs) derived from lymphocytes of patients with Graves’disease: epitope and binding study of two stimulatory TRAbs[].The Journal of Endocrinology.1999
  • 4Simanainen J,Kinch A,Westermark K,et al.Analysis of mutations in exon 1 of the human thyrotropin receptor gene:high frequency of the D36H and P52T polymorphic variants[].Thyroid.1999
  • 5Seetharamaiah G S,Dallas J S,Prabhakar B S.Glycosylated ectodomain of the human thyrotropin receptor induces antibodies capable of reacting with multiple blocking antibody epitopes[].Autoimmunity.1999
  • 6Schwarz-Lauer L,Chazenbalk G D,Mclachlan S M,et al.Evidence for a simplified view of autoantibody interactions with the thyrotropin receptor[].Thyroid.2002
  • 7Shepherd P S,Da Costa C R,Cridland J C,et al.Identification of an important thyrotrophin binding site on the human thyrotrophin receptor using monoclonal antibodies[].Molecular and Cellular Endocrinology.1999
  • 8Li X,Lu S,Miyagi E,et al.Thyrotropin prevents apoptosis by promoting cell adhesion and cell cycle progression in FRTL-5[].The Journal of Endocrinology.1999
  • 9Abe Y.Apoptosis in the pathogenesis of autoimmune thyroid disease[].Japanese Journal of Clinical Medicine.1999
  • 10Chazenbalk G D,McLachlan S M,Pichurin P,et al.A prion-like shift between two conformational forms of a recombinant thyrotropin receptor A-subunit module: purification and stabilization using chemical chaperones of the form reactive with Graves’autoantibodies[].The Journal of Clinical Endocrinology.2001

同被引文献69

  • 1何云南.游离三碘甲状腺原氨酸(FT_3)放射免疫分析的临床应用[J].放射免疫学杂志,1995,8(6):458-459. 被引量：1
  • 2连小兰,白耀,孙梅励,郭芝生,戴为信.血清抗甲状腺球蛋白抗体和抗甲状腺过氧化物酶抗体测定的临床诊断意义[J].中国医学科学院学报,2004,26(6):677-681. 被引量：38
  • 3徐健,刘小立,杨雪锋,李兰英,孙云,孙秀发.过量碘对甲状腺细胞凋亡的影响[J].卫生研究,2007,36(4):443-445. 被引量：14
  • 4Tomer Y, Barbesino G, Keddache M, et al. Mapping of a major sus- ceptibility locus for Graves~ disease (GD- 1 ) to chromosome 14q31. J Clin Endocrinol Metab, 1997, 82(5 ): 1645-1648.
  • 5AkamizuT, MoriyamaK, MiuraM, et ak Characterization of recombinant monoclonal antithyrotropin receptor antibodies (TSHRAbs)derived from lymphocytes of patients with Graves" disease: epitope and binding study of two stimulatory TSHRAbs. Endocrinology, 1999, 140(4): 1594-1601.
  • 6Marians RC, Ng L, Blair HC, et al. Defining thyrotropin-dependent and -independent steps of thyroid hormone synthesis by using thy- rotropin receptor-null mice. Proc Natl Acad Sci USA, 2002, 99 (24): 15776-15781.
  • 7Garcia-JimOnez C, Santisteban P. TSH signalling and cancer. Arq Bras Endocrinol Metabol, 2007, 51 (5): 654-671.
  • 8Hoffmann S, Maschuw K, Hassan I, et al. Functional thyrotropin receptor attenuates malignant phenotype of follicular thyroid caneer cells. Endocrine, 2006, 30( 1 ): 129-138.
  • 9Rivas M, Santisteban P. TSH-activated signaling pathways in thy-roid tumorigenesis. Mol Cell Endocrinol, 2003, 213 ( 1 ): 31-45.
  • 10Xing M, Usadel H, Cohen Y, et al. Methylation of the thyroid-stim- ulating hormone receptor gene in epithelial thyroid tumors: a mark- er of malignancy and a cause of gene silencing. Cancer Res, 2003 63(9): 2316-2321.

引证文献7

二级引证文献17

国外医学（内分泌学分册）
2003年 第1期

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