摘要
目的 :比较正常早孕组与流产组蜕膜催乳素 (PRL)、孕酮 (P)、雌二醇 (E2 )及其受体水平的差异 ,探讨它们在维持早孕中的作用。方法 :收集正常早孕人工流产 18例与保胎失败流产的 12例蜕膜组织 ,应用放免法测定蜕膜匀浆PRL、P、E2 水平 ,并用免疫组化方法检测了相应激素受体 (PRLR、PR、ER)的表达。结果 :正常早孕组蜕膜匀浆PRL、P水平显著高于流产组 (P <0 .0 5 ) ,正常早孕组PRLR、PR表达亦显著高于流产组 (P <0 .0 5&0 .0 1)。结论 :蜕膜局部正常水平的PRL。
Objective:To compare the difference of PRL?P?E 2 and their receptors in normal and abortional decidue and explore their effects on maintaining of pregnancy.Methods:We collected decidue from 18 normal early pregnancy women who desired conducting induced abortion and decidue from 12 women who failed to preventing miscarriage.RIA was carried out to measure the local hormone levels, and the expression of PRLR,PR,ER was detected immunohistochemically.Results:The decidue PRL,P levels of normal early pregnancy group were significantly higher than those of miscarriage group(P<0.05), the same as PRLR and PR expression(P<0.05,P<0.01 respectively).Conclusion:The normal excretion of PRL,P and the normal expression of their receptors in decidue are important in maintaining early pregnancy.
出处
《现代妇产科进展》
CSCD
2003年第1期40-42,共3页
Progress in Obstetrics and Gynecology
关键词
正常早孕
流产
蜕膜
催乳素
孕酮
雌二醇
孕酮受体
雌二醇受体
Decidue
Abortion
Prolactin
Receptors,prolactin
Progesterone
Receptors,progesterone
Estradiol
Receptors,estradiol
