1Denis H, Lacroix JC. The dichotomy between germ line and somatic line, and the origin of cell mortalit[J]. Trends Genet,1993,9(1):7-11.
2Lundberg AS, Hahn WC, Gupta P, et al. Genes involved in senescence and immortalization[J]. Current Opinion in Cell Biology, 2000, 12:705-709.
3Blackburn EH. Structure and function of telomeres[J]. Nature,1991,350(6319):569-573.
4Harley CB, Futcher AB, Greider CW. Telomeres shorten during ageing of human fibroblasts[J]. Nature,1990 ,345(6274):458-460.
5Counter CM. The roles of telomeres and telomerase in cell life span[J]. Mut Res,1995,366:45-63.
6Zglinicki T, Saretzki G, Docke W, et al. Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts: a model for senescence[J]. Exp Cell Res, 1995, 220:186-193.
7Chen Q, Ames BN. Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells[J]. Proc Natl Acad Sci USA,1994, 91:4130-4134.
8Serrano M, Lin AW, Mccurrach ME, et al. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a[J]. Cell, 1997, 88:593-602.
9Shay JW, Wright WE, Werbin H. Defining the molecular mechanisms of human cell immortalization [J]. Biochim Biophys Acta,1991 ,1072(1):1-7.
10Katakura Y, Alam S, Shirahata S. Immortalization by gene transfection[J]. Methods Cell Biol. 1998,57:69-91.
