摘要
目的 探讨血小板衍生生长因子 (PDGF)在肺鳞状细胞癌 (肺鳞癌 )中的表达及意义。方法 应用免疫组织化学技术观察了PDGF A链和PDGF B链在 2 8例肺鳞癌中的表达 ,并与其在肺非特异性炎症组织中的表达相比较。结果 PDGF A链和PDGF B链的表达主要定位于肿瘤细胞胞浆、血管内皮细胞及平滑肌细胞 ,炎症组织的肺泡上皮细胞及血管平滑肌细胞少量表达。PDGF A链和PDGF B链在肺鳞癌中有显著表达。结论 PDGF A链和PDGF B链的过表达与肺鳞癌可能有关 。
Objective To explore the expression of PDGF in lung squamous cell carcinoma. Methods using immunohistochemical methods, the expression of PDGF A chain and PDGF B chain were analyzed in 28 lung squamous cell carcinomas, and were compaired with the expression in non specific inflammation of lung tissues. Results PDGF were localized in cytoplasma of tumor cells and mesenchymal and endothelial cells of lung squamous cell carcinoma. Slight expression could found in aleveolar epitheliar cells and vascular endothelial cells in control lung tissues. There were significant overexpression of PDGF A chain and PDGF B chain in lung squamous cell carcinoma. Conclusions The overexpression of PDGF A chain and PDGF B chain could play a potential role in lung squamous cell carcinoma,but the overexpression were not associated with the pathological stage of the cancer.[
出处
《合肥医学院学报》
2002年第6期501-502,共2页
Journal of Zunyi Medical University
基金
贵州省卫生厅科研基金项目 (NO :D 12 4 )
关键词
血小板衍生生长因子
肺鳞状细胞癌
表达
Platelet derived growth factor
Lung squamous cell carcinoma
expression
