摘要
根据 2 0 0 1年北京市中年职业人群 2 915人的年度体检资料 ,结合作者以往对血脂临床研究的经验 ,定量地观察了血清甘油三酯对高密度脂蛋白胆固醇水平的影响和新提出的甘油三酯与高密度脂蛋白胆固醇比值 ,探讨甘油三酯与高密度脂蛋白胆固醇合适水平及动脉粥样硬化性心血管病的危险水平。结果发现高密度脂蛋白胆固醇水平低于 0 .9mmol L者少于 5 % ,低于美国白人 ;随高密度脂蛋白胆固醇降低甘油三酯呈梯度升高 ,甘油三酯为1.14mmol L时相应的高密度脂蛋白胆固醇不论男女都在合适水平 ,甘油三酯 >1.7mmol L时 ,女性高密度脂蛋白胆固醇已略有降低 ,甘油三酯 >2 .2 7mmol L时高密度脂蛋白胆固醇明显偏低。因此我们主张参考美国国家胆固醇教育计划 (ATPⅢ )指南 ,将中国人的低高密度脂蛋白胆固醇的诊断界限以 <0 .9mmol L代替过去制定的 <1.0 3mmol L。此研究提示以前所定甘油三酯合适水平 (<1.7mmol L)是恰当的 ,但应以甘油三酯 1.7～ 2 .2 6mmol L作为边缘性增高 (即临界范围 ) ,>2 .2 7mmol L为高甘油三酯血症。甘油三酯与高密度脂蛋白胆固醇合适比值为 2～ 3(mg mg)。
Aim To discuss the desirable and risk level of triglyceride (TG) and high density lipoprotein cholesterol (HDLC) in cardiovascular diseases. Methods Serum lipids of 2915 middle aged subjects of Beijing professional population were studied during annual physical surveys in year 2001. The effects of different levels of TG on HDLC and TG/HDLC ratio were analyzed statistically. Results HDLC level was relatively low as compared with that of the American whites, less then 5% in this studied group had HDLC below 0.9 mmol/L. According to our long term prospective study of the elderly, HDLC level above 1.03 mmol/L may be considered as desirable. Gradient increase in TG level was accompanied by progressive decrease in HDLC. While TG at 1.14 mmol/L, HDLC levels of both sexes were at desirable level, but with slight decrease in females when the TG level up to >1.7 mmol/L, marked decrease in both sexes when TG increased to>2.27 mmol/L. The acceptable TG/HDLC ratio was about 2 3 (by mg/mg). Conclusion According to this study and our previous experience, we propose that it may be appropriate to adopt the TG and HDLC level classification of ATPШ guidelines of the National Cholesterol Education Program of United States.
出处
《中国动脉硬化杂志》
CAS
CSCD
2002年第6期513-516,共4页
Chinese Journal of Arteriosclerosis
