摘要
目的 :探讨外用纤维蛋白胶 (FS)对猪深二度烫伤创面愈合的影响。 方法 :采用猪深二度烫伤模型 ,创面外用FS。通过伤后不同时相点创面取材 ,检测羟脯氨酸 (OHP)、细胞周期、创面组织含水量、创面愈合时间及组织病理形态学改变 ,以 1%磺胺嘧啶银霜 (Ag SD)作对照 ,观察FS对猪深二度烫伤创面愈合的影响。 结果 :FS组OHP含量显著高于Ag SD组 ;FS组创面S期细胞百分比显著高于Ag SD组 (P <0 .0 5 ) ;创面愈合时间分别为FS组 (10 .2± 1.31)天 ,Ag SD组 (12 .4± 1.14 )天 ,差异显著 (P <0 .0 5 ) ;提示FS组创面组织肿胀较Ag SD组轻。病理形态改变提示FS组上皮细胞和成纤维细胞增生良好。 结论 :FS有明显的促进创面愈合作用 ,局部OHP含量增高 ,S期细胞百分比升高 ,水肿减轻 。
Objectives:To investigate the effect of Fibrin sponge(FS) on the deep second degree scalded wounds of pigs. Methods: The deep second degree scalded wounds of pigs were treated by FS and 1%Ag SD(control),respectively.The wound healing times,the content of hydroxyproline(OHP),the water ratio,the cycle of cells as well as the pathological changing of the wound tissues were examinated at different points post scalded.so as to value the effect of FS on the healing of the deep second degree scalded wounds of pigs. Results:Compared with the 1%Ag SD group,The healing time of the FS group(10.2±1.31days) was shorter than the 1%Ag SD group(12.4±1.14 days, P <0.05),Compared with the 1%Ag SD group,the content of OHP was obviously higher,the water ratio was lower and the ratio of cells in s peroid was higher( P <0.05) in wounds of the FS group.It was indicated by histopathologic examination that the proliferation conditions of epithelium and fibroblast cells were much better in FS group. Conclusions: External using FS on the deep second degree scalded wounds of pigs could improve the wound condition and shorten the heling time.
出处
《医学研究生学报》
CAS
2002年第6期474-477,F003,共5页
Journal of Medical Postgraduates
基金
国家重点基础研究发展规划项目 (批准号 :3 9870 85 9)
