摘要
目的 探讨脑囊虫病患者体内γ-干扰素 (IFN-γ)和白细胞介素 - 10 (IL - 10 )的水平。 方法 采用逆转录聚合酶链式反应 (RT- PCR)检测 2 7例脑囊虫病患者外周血单个核细胞产生 IFN-γ(代表 Th1水平 )和 IL - 10 (代表 Th2水平 )两种细胞因子的变化。 结果 2 4例有细胞因子表达 ,3例未测出。在 2 4例有细胞因子表达的患者中 ,7例表达 IFN-γ和 IL - 10两种细胞因子 ,17例仅表达 IL- 10。 结论 脑囊虫病患者存在 Th1/ Th2的漂移现象 ,明显表现为 Th2型细胞因子表达 ,细胞免疫功能低下 ,而体液免疫功能升高 ,存在 Th1/ Th2平衡失调。
Objective To investigate the levels of IFN γ and IL 10 in patients with neurocysticercosis. Methods Monocyte in peripheral blood of 27 patients with neurocysticercosis were detected by RT PCR. Results Cytokines were detected out in 24 cases and the other 3 cases were not. Among 24 positive cases, the mRNA of IFN γ and IL 10 were detected in 7 cases, whereas the mRNA of IL 10 was only detected in 17 cases. Conclusion The obvious increase of Th2 cell subgroup associated with IL 10 and decrease of Th1 cell subgroup associated with IFN γ indicated that the patients' cellular immune function was very weak, whereas the humoral immunocompetence was relatively strong.
出处
《中国寄生虫病防治杂志》
CSCD
2002年第6期365-366,共2页
Chinese Journal of Parasitic Disease Control
