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精子发生相关基因的分子遗传学研究进展 被引量：12

Research Progress for Spermatogenesis-related Genes in Molecular Genetics
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摘要 特发性无精、严重少精症的分子遗传学研究越来越广泛深入。近年来,控制精子发生的相关基因,主要包括位于Y染色体AZFa区的USP9Y和DBY、AZFb区的RBM基因、AZFc区的DAZ基因,和位于常染色体的DAZLA基因等在分子遗传学研究方面均取得了可喜的进展。对这方面的研究进展及其展望进行了综述。 More and more progress in molecular genetics were, made in the study of azoospermia and severe oligo-zoospermia. Recently, in the research of spermatogenesis-related genes, including USP9Y and DBY gene of AZFa, RBM gene of AZFb and DAZ gene of AZFc in Y chromosome, and DAZLA gene in autosome, great progress were made. In this paper these progress and its significance were reviewed.
作者 傅俊江 李麓芸 卢光琇
机构地区 中南大学湘雅医学院人类生殖工程研究室
出处 《生殖与避孕》 CAS CSCD 北大核心 2002年第6期367-371,共5页 Reproduction and Contraception
基金 国家重点基础研究发展规划项目(973课题)资助(批准号:G1999055901)
关键词 男性不育 精子发生 基因 遗传学 male infertility, spermatogenesis, gene, genetics
分类号 R394 [医药卫生—医学遗传学]
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参考文献21

  • 1Brown, GM, Furlong, RA, Sargent CA, et al. Characterisation of the coding sequence and fine mapping of the human DFFRY gene and comparative expression analysis and mapping to the Sxr-b interval of the mouse Y chromosome of the Dffry gene. Hum Mole Genet, 1998, 7:97～107.
  • 2Sun C, Skaletsky H, Bruce B, et al. An azoospermic man with a de novo point mutation in the Y-chromosomalgene. USP9YNat Genet, 1999, 23:429～432.
  • 3Foresta C, Ferlin A & Moro E. Deletion and expression analysis of AZFa genes on the human Y chromosome revealed a major role for DBY in male infertility.Human Molecular Genetics, 2000, 9 (8): 1161～169.
  • 4Sargent CA, Boucher CA, Kirsch S, et al. The critical region of overlap defining the AZFa male infertility interval of proximal Yq contains three transcribed sequences. J Med Genet, 1999, 36:670～677.
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  • 6Saxena R. , Brown LC, Hawkins T, et al. The DAZ gene cluster on the human Y chromosome arose from an autosomal gene that was transposed, repeatedly amplified and pruned. Nature Genet 1996, 14:292～299.
  • 7Vogt PH, Edenlmann A, Kirsch S, et al. Human Y chromosome azoospermia factors (AZF) mapped to different subregions in Yqll. Hum Mol Genet, 1996,5:933～943.
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生殖与避孕
2002年 第6期

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