摘要
目的 研究脑肿瘤患者术前及术后血清中可溶性白介素 2受体及肿瘤坏死因子α的水平及其表达意义。方法 在术前、术后 2周、术后 3个月分别测定了 4 7例星形细胞瘤、2 2例脑膜瘤、2 5例脑转移瘤血清中可溶性白介素 2受体及肿瘤坏死因子α的水平。结果 术前脑肿瘤患者的白介素 2受体、TNF -α较正常均明显升高。术后 2周及 3个月 ,脑膜瘤患者的sIL - 2R、TNF -α较术前均明显下降。星形细胞 3— 4级、转移瘤患者的白介素 - 2R、TNF -α的测定较术前改变不明显。将死亡与未死亡患者术前的sIL - 2R进行比较 ,我们发现死亡组的sIL - 2R的测定明显高于未死亡组。结论 sIL - 2R及TNF -α的表达与肿瘤类型有关。sIL - 2R及TNF
Objective To investigate the role of soluble interleukin 2 receptor and tumor necrosis factor,we studied the changes of serum sIL-2R and TNF-α in patients with brain tumors.Methods sIL-2R and TNF-α was measured in 94 patients with brain tumors(47 gliomas,22 menigioma,25 cancer metastasis).The investigation was performed serial preoperative,2 weeks postoperative,3 months postoperative.Results The preoperative levels of sIL-2R and TNF-α were significantly different from levels in normal volunteers.After operation,the level of SIL-2R and TNF-α in patients with menigioma decreased obviously while patients with astrocytoma or cancer metastasis changed little.In patients with astrocytoma and cancer metastasis,the preoperative level of sIL2-R and TNF-α in mortality group siginificantly different from survived.Conclusions The level of sIL2-R and TNF-α correlated with the type of brain tumor.Serum levels of sIL-2R and TNF-α could be useful immunological marker in patients with brain tumors.
出处
《河南实用神经疾病杂志》
2003年第1期1-2,共2页
Henan Journal of Practical Nervous Diseases
