1[1]Weinblatt ME,Coblyn JS,Fox DA,et al.Efficacy of low-dose methotrexate in rheumatoid arthritis.N Engl J Med,1985,312:818
2[2]Fries JF,Singh G,Lenert L.Aspirin,hydroxychloroquine,and hepatic enzyme abnormalities with methotrexate in rheumatoid arthritis.Arthritis Rheum,1990,33:1611
3[3]Albers JM,Paimela L,Kurki P,et al.Treatment strategy,disease activity,and outcome in four cohorts of patients with early rheumatoid arthritis.Ann Rheum Dis,2001,60:453
4[4]Calabrese LH.Rheumatoid arthritis and primary care:the case for early diagnosis and treatment.J Am Osteopath Assoc,1999,11:313
5[5]O'Dell JR,Haire CE,Erikson N,et al.Treatment of rheumatoid arthritis with methotrexate alone,sulfasalazine and hydroxychloroquine,or a combination of all three medications.N Engl J Med,1996,334:1287
6[6]Tim G,Montagna G,Salaffi F,et al.Combination therapy with cyclosporin and hydroxychloroquine in early active severe rheumatoid arthritis.Abstracts of the ACR,1997 National Meeting,397
7[7]Weinblatt ME,Kaplen H,Gernard BF,et al.Methotrexate in rheumatoid arthritis.Arthritis Rheum,1994,38(10):1492
8[8]Fox RI.Mechanism of action of hydroxychloroquine as an antirheumatic drug.Semin Arthritis Rheum,1993,23(suppl):82
10Sokka T,Pincus T.Contemporary disease modifying antirheumatic drugs(DMABD)in patients with recent onset rheumatoid arthritis in a US private practiee:methotrexate as the anchor drug in 90% and new DMARD in 30% of patients[J].J Rheumatol,2002,29(12):2521-2524.