摘要
背景与目的:以往认为,细胞核DNA含量和核仁组成区嗜银蛋白(silver-stainingnucleolarorganizerregion,AgNOR)计数在某些肿瘤中有重要的预后意义,但对卵巢囊腺癌患者的预后意义尚不清楚。为此,本研究探讨该两项细胞增殖参数对预测卵巢囊腺癌患者预后的价值。方法:对42例卵巢囊腺癌切除术的组织标本采用图像分析仪测定核DNA含量和AgNOR颗粒计数,将结果与预后情况进行分析。结果:单因素生存率分析显示,差异有统计学意义的临床变量为FIGO分级、分化程度、残余肿瘤大小、肿瘤转移灶、淋巴结转移情况和年龄、异倍体、DNA指数、AgNOR颗粒计数(P<0.05)。多因素生存率分析显示,DNA指数>1.4、FIGO分级、分化程度和残余肿瘤大小是卵巢囊腺癌的具有统计学意义的预后预测因子。结论:对于卵巢囊腺癌患者来说,细胞核DNA指数可能是有用的预后独立预测因子。
BACKGROUND &OBJECTIVE:It has been showed that cellular DNA content and silver-staining nuc leolar org anizer reg ion(Ag NOR)count were sig nificantly associated with the p rog nosis of some tumors;however,it is not yet clear whether these two parameters b e helpful in predicting the prog nosi s of ovarian cystadenoma.This study was desig ned to evaluate the prog nostic sig nificance of these two parameter s in ovarian cystadenoma.METHODS :Cellular DNA content and Ag NOR count of the tumor cells for the samples fro m42patients with ovarian cystadenom a were measured by using computerize d imag e analysis.The relationship be tween clinical as well as histomorpholog ic factors and the overall survival was evaluated by multivariable analysi s.RESULTS :Univariate analysis showed that Ag N OR count,DNA index,FIGO stag e,deg ree of differentiation,p resence of distant metastasis,resi dual tumor,lymph node metastasis,and ag e were t he clinical variates with sig nificant difference(P<0.05).Multivariate analysis showed that DNA index >1.4,FIGO stag e,deg ree of differentiation,and residual tumor were prog nost ic predictors of ovarian cystadenoma.CONCLUSION:The DNA index may be a useful independent factor for predi cting the diag nosis of ovarian cysta denoma.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
2003年第1期62-65,共4页
Chinese Journal of Cancer
