摘要
反义技术是应用反义寡核苷酸来选择性地封闭基因表达的一项新兴的生物技术。它的出现掀起了基础、临床及药物开发领域新一轮的技术革命。简述了反义技术的理论机制、反义核酸的种类、应具备的特性及在相关领域中的应用。
Antisense strategy is a kind of newly rising biotechnology which can selectively block gene expression by using sequence-specific antisense oligonucleotides.Its emergence stired up a new technical revolution in tbe fields of basic research,clinical trial and drug development.The mechanism,classification and characteristics of antisense oligonucleotides and its application in relative fields are reviewed.
出处
《科学技术与工程》
2002年第6期78-81,共4页
Science Technology and Engineering
基金
总后勤部"十五"科研基金(01MA075)资助
关键词
反义技术
生物技术
反义核酸
反义寡核苷酸
antisense technology
antisense oligonucleotide
application of antisense technology
