摘要
目的 :观察应用国产干扰素 (赛若金 )治疗慢性乙型肝炎的疗效 ,并进行随访。方法 :84例慢性乙型肝炎患者随机分为两组 ,治疗组42例 ,应用国产干扰素IFNα1b(商品名 :赛若金 )肌肉注射 ,1周3次 ,1次5MU ,对照组42例 ,使用常规保肝药物 ,两组疗程均为6个月。结果 :疗效结束时 ,两组临床症状及体征改善 ,治疗组优于对照组 (P<0 01) ,治疗组肝功能指标ALT恢复率89 6 %优于对照组ALT恢复率51 3 % (P<0 05)。停药后2年随访结果比较 ,治疗组HBsAg阴转率 ,HBVDNA阴转率及HBeAgHBVDNA双阴转率分别为45 9 %、54 2 %和40 5 % ,与对照组比较P<0 01 ,差异有非常显著意义。结论 :IFNα1b(赛若金 )对治疗慢性乙型肝炎的疗效 ,无论是近期还是远期 。
Objective:To observe the effects of domestic Interferon-α 1b(Sinogen) on chronic hepatitis B and follow-up study.Methods:84 cases with chronic hepatitis B were randomly divided into two groups,treated group(IFN-α 1b group) including 42 cases was given IFN-α 1b in 500U,three weekly,while control group including 42 cases was taken regulur regimen.Treatment 6 months.Results:At the end of treatment,the effect in treated group was higher than that in control group(P<0 01).The ALT normalizution rate of treated group was 89.6%,the control group was 51.3%,and treated group was better than control group(P<0.05).After two years follow-up study,the HBeAg scrconversion rate the HBV-DNA seroconversion rate and the HBeAg HBV-DNA double seroconversion rate of treated group was 45.9%,54.2% and 40.5%.There was siginficantly differnce between treated group and control group(P<0.01).Conclusion:Either short-term or long-term effect of IFN-α 1b (Sinogen) treatment in chronic hepatitis B is effective. [
出处
《现代医药卫生》
2003年第1期11-12,共2页
Journal of Modern Medicine & Health
关键词
国产
干扰素
慢性乙型肝炎
治疗
Domestic interferon-a 1b Chronic hepatitis B
