摘要
目的:评价含紫杉醇(泰素)的联合化疗方案治疗晚期乳腺癌的疗效和毒副作用。方法:经病理确诊的晚期乳腺癌30例,化疗前常规标准化抗过敏治疗,然后开始全身化疗。方案:泰素175mg/m2静滴第一天,阿霉素40 mg/m2,静注第1-2天,环磷酰胺400 mg/m2,静注第1、8天,氟尿嘧啶500 mg/m2静滴第1、8天,28天重复一次,连用2个周期为一个疗程。结果:CR 3例,PR 16例,有效率为63.3％。全组中位缓解期为9个月。主要的毒副作用为骨髓抑制、脱发、肌肉/关节疼痛和周围神经痛,均为轻中度,停药后可恢复。未发生任何过敏反应。结论:含紫杉醇的联合化疗方案治疗晚期乳腺癌,疗效肯定,毒副作用可以耐受,值得推广为第二线治疗方案。
Purpose: To evaluate the therapeutic effect and toxicities of paclitaxel combined chemotherapy regimens in the treatment of advanced breast cancer. Methods: 30 cases with advanced breast cancer verified by pathology were given routinely standard anti-hypersensitive treatment before systematic chemotherapy. In combination regimens, Taxol was given 175 mg/m by intravenous( i. v.) infusion on dayl, cyclophosphamide 400mg/m i. v. on day 1, day 8, 5-fluouracil 500 mg/ m i. v. on day 1, day 8. Drugs were repeated every 28 days and one course consisted of 2 cycles. Results: 3 patients showed complete response and 16 patients showed partial response. The overall response rate was 63. 3%. The median duration of remission was 9 months. The major toxic effects including myelosuppression, myalgia/arthralgta and peripheral neuropathy, were mild or moderate. There was no hypersensitivity. The side-effects disappeared after stopping chemotherapy. Conclusions: Taxol combined with chemotherapy regimens are an effective treatment for patients with advanced breast cancer, The toxicity of the treatment are tolerated by the patients. These regimens are worthy of recommendation as second-line chemotherapy.
出处
《中国癌症杂志》
CAS
CSCD
2002年第6期535-537,共3页
China Oncology
关键词
含紫杉醇
化疗
治疗
晚期
乳腺癌
breast neoplasms
paclitaxel
combined chemotherapy
