摘要
目的 为对动脉瘤经国产钨弹簧圈栓塞后的病理变化进一步进行估价。方法 建立犬的动脉瘤模型18枚,以国产可控电解钨弹簧圈进行栓塞,栓塞后24h、2周、2月和6月行血管造影复查,并立即随机抽取动物处死,取动脉瘤进行光电镜观察。结果 动脉瘤模型完全闭塞13例,大部闭塞5例。2例在2周复查时发现残腔扩大行二次栓塞。病理检查发现栓塞后24h,动脉瘤内被弹簧圈及血栓所紧密填充。2周后动脉瘤颈部被新生的内皮组织所封闭。2个月后动脉瘤腔内的血栓完全机化,动脉瘤颈部被成熟的内皮细胞封闭,内皮细胞下为完整的结缔组织层和肉芽组织层。结论 应用钨弹簧圈栓塞动脉瘤后可诱发动脉瘤腔内血栓形成和机化,以及动脉瘤颈部内皮细胞和结缔组织生长。这些病理变化是动脉瘤治愈的病理学标志。
Objective To evaluate the pathological changes in aneurysms after the embolization with tungsten coils. Methods Eighteen aneurysmal models established in 14 dogs were embolized by self-made electrolytic detachable tungsten coils. Angiographic examinations were carried out 24 hours, 2 weeks, 2 months after the embolization. The animals were randomly killed after the examinations, and the aneurysms were resected for pathological examinations including electron and light microscope observations. Results Of the 18 aneurysms, 13 were totally occluded and 5 subtotally. The second embolizations were performed in 2 aneurysms 2 weeks after the first embolization due to the enlargements of residual parts. The aneurysms were pathologically found to be compactly fdled by coil and thrombosis 24 hours after the embolization. There were newborn endothlium cells around the aneurysms necks two weeks after the embolization. The intraluminal thrombosis was totally organized and there were mature endothelium cells, under which there were the intact layers of connective and granulation tissues around the aneurysms necks two months after the embolization. Conclusions The tungsten coils in the aneurysms can produce intraluminal thrombosis and organization, and endothlium cells and connective tissue growing around the aneurysm necks, which are the histological indication of the healed aneurysm.
出处
《中国临床神经外科杂志》
2002年第6期358-359,共2页
Chinese Journal of Clinical Neurosurgery
基金
国家"九五"攻关课题资金资助(课题号:96-907-02-02)
关键词
实验研究
电解脱弹簧圈
栓塞
动脉瘤
Electrolyte detachable coils
Embolization
Aneurysms
Dogs
