摘要
质量分数为 1 0 %的壳聚糖溶液通过乳液法与戊二醛交联合成了壳聚糖微球 ( CM) ,在其表面吸附一层 Fe3 O4制得磁性壳聚糖微球 ( MCM)。用扫描电镜、红外光谱仪、原子吸收分光光度计和紫外吸收分光光度计对合成的高分子微球进行了形貌观察和结构表征。结果表明 ,降低壳聚糖的分子量 ,有利于合成单分散性好、粒径小 ( <1 μm)的微球 ;体外测试表明 ,CM包封阿斯匹林 ( AS)微球 ( CM-AS)在 1 h内释药量达 4 0 % ,而MCM-AS仅为 1 5 % ,CM-AS和 MCM-AS释药量达 5 0 %的时间分别为 1 .4和 5 h;MCM和 MCM-AS均具有较强的磁性 ,后者在外磁场作用下能够实现靶向给药。
Chitosan microspheres(CM) were prepared by cross-linking of glutaraldehyde with chitosan solution(mass fraction 10%), and coated with Fe 3O 4 to give magnetic chitosan microspheres(MCM). SEM, IR, atomic absorption spectrometry and UV results indicated that the size of the polymer particles became smaller (<1 μm) and more uniformly distributed with decrease of the chitosan molecular weight. In vitro measurement showed the CM entrapped with Aspirin(CM-AS) released about 40% drug, while MCM-AS released 15% in period within one hour. The releasing times for 50% drug were 1.5 h and 5 h, respectively, for CM-AS and MCM-AS. Both MCM and MCM-AS showed strongly magnetic response and promizing applications as targeting drug releasing agent.
出处
《应用化学》
CAS
CSCD
北大核心
2002年第12期1178-1182,共5页
Chinese Journal of Applied Chemistry
基金
河北省教育厅科学基金资助课题 ( 2 0 0 2 2 2 3)
