摘要
目的 探讨猪胸主动脉的生物力学特性变化。方法 取 1～ 9月龄猪的胸主动脉各 6例 ,从每例标本的中段处将血管切为短圆环 ;将 7月龄猪胸主动脉分为上、中、下段 ,每段再分为 5个短圆环。将各血管沿其径向剪开 ,测量张开角的大小、壁厚和周长 ,并依周长计算出等效内径。结果 猪胸主动脉张开角由 1月的 (42 .1 7± 4 .0 6)°上升到 7月的 (76.2 2± 4 .4 0 )°,在 7月龄后达到稳定。对 7月龄猪胸主动脉自上而下分析则发现张开角由 (99.73± 6.79)°降至 (42 .0 9± 7.4 0 )°。壁厚 等效内径值随月龄增加而减小 ,于 7月龄后保持于 0 .1 8左右。结论 猪胸主动脉张开角、等效内径和壁厚随月龄的增加而增大 ;随着X L的增加各项指标均逐渐减小 ,血管的内外径在 7月龄后成比例生长。
Objective To explore the biomechanical properties of pig thoracic aorta. Methods 54 pig thoracic aortas aged from 1 to 9 months old were observed by cutting the middle regional vessels into short segments. Thoracic aortas from 7-month-old pigs were divided into three regions: superior, middle and inferior regions and each region was redivided into 5 shorter segments. The equivalent inner diameter and the mean wall thickness were measured after every segment has been cut radially for 20 minutes. Results With age the opening angle of pig thoracic aorta aged from 1 to 7 months old increased from (42.17±4.06)° to (76.22±4.40)°, after 7 th months became stable ,while in the same age pigs the opening angle of thoracic aorta decreased from (99.73±6.79)° in the superior region to (42. 09±7.40)° in the inferior region. The ratio of the wall thickness and the equivalent inner diameter decreased with age and stayed at about 0.18 after 7th months. Conclusion The opening angle, wall thickness and equivalent inner diameter of the studied pig thoracic aortas increase with age, but tend to decrease with the longitudinal distance X/L increasing. The inner and outer diameters increase after 7th months simultaneously. The results are useful for providing essential data for pig→human vascular xenotransplantation and analyzing the pathological recovery and remodeling process.
出处
《医用生物力学》
EI
CAS
CSCD
2002年第4期220-224,共5页
Journal of Medical Biomechanics
基金
湖北省卫生厅重点项目资助 (WJ0 15 3 9)
关键词
猪
胸主动脉
重建
张开角
生物力学
Pig
Thoracic aorta
Remodeling
Opening angle
Biomechanics
