摘要
目的 :探讨胆红素与血脂的综合指数对冠心病 (CHD)的诊断价值。方法 :将 15 4例行冠状动脉 (冠脉 )造影术者 ,按照冠脉造影结果分为 3组 :CHD高度狭窄组、中度狭窄组 ,冠脉正常组 ,分析组间血脂、胆红素及综合指数的差异及其对CHD的预测符合率。结果 :CHD组患者血清总胆红素 (TBil)明显低于冠脉正常组 (P <0 .0 1) ,血清总胆固醇 (TC)、低密度脂蛋白胆固醇 (LDL C) ,LDL C [高密度脂蛋白胆固醇 (HDL C) +TBil]比值、TC (HDL C +TBil)比值水平明显高于冠脉正常组 (P <0 .0 5或P <0 .0 1)。进行判别分析 ,将LDL C (HDL C +TBil)与传统危险因素 (HDL C、LDL C、TC、年龄、收缩压、血糖 )同时引入模型 ,年龄与LDL C (HDL C +TBil)进入模型 ,显示出较其他各项指标与CHD更强的相关性 ,且对CHD的预测符合率为 5 8.6 % ,高于传统危险因素对CHD预测符合率 (P <0 .0 5 )。结论
Objective:To study the significance of composite index of the serum bilirubin and serum lipid variables in predicting coronary heart disease rk.Methods:A total of 154 patients who had undergone coronary angiography entered the study. Their results of coronary angiography were investigated and they were divided into three groups: ① severe stenochoria ②middle stenochoria ③normal. Serum bilirubin, the traditional risk factors of cholesterol(TC), high density lipoprotein cholesterol(HDL C), Low density lipoprotein cholesterol(LDL C), triglycerides(TG) were tested by discriminant analysis as were TC/HDL C, LDL C/HDL C, TC/(HDL C+bilirubin) and LDL C/(HDL C+bilirubin).Results:Each of these bilirubin containing ratios was found to be an independent risk predictor when tested with the traditional risk factors. When the LDL C/(HDL C+bilirubin) ratio was included with the traditional risk predictors, it elevated the rate of overall correct Conformity of CHD from 44.7 % to 58.6 %.Conclusion:Serum bilirubin can be combined with LDL C/HDL C ratio, TC/HDL C ratios to improved the prediction of CHD.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2002年第12期617-619,共3页
Journal of Clinical Cardiology
