摘要
目的 :探讨幽门螺杆菌 (Hp)感染与冠心病 (CHD)急性心肌梗死 (AMI)的关系。方法 :测定 5 1例AMI和 4 2例陈旧性心肌梗死 (OMI)患者及 31例冠状动脉造影正常者 (对照组 )的Hp特异性抗体 (HpIgG、HpIgM)浓度 ,并同步观察血浆C 反应蛋白 (CRP)、血清脂质变化及其与Hp感染的相关性。结果 :AMI组HpIgG、HpIgM阳性率及平均浓度 (或OD值 )明显高于对照组 (P <0 .0 5 )。校正CHD危险因素前、后 ,HpIgG阳性与AMI均具有相关关系。AMI组HpIgG、总胆固醇 (TC)、甘油三酯 (TG)、低密度脂蛋白胆固醇 (LDL C)明显高于对照组 ;CRP高于对照组及OMI组。AMI组中Hp(+)者CRP、TG明显高于 ,HDL C明显低于Hp(- )者 (P <0 .0 5 )及OMI组中Hp(+)者 (P <0 .0 1) ;并且IgG与CRP、TC、LDL C呈正相关 ,与HDL C呈负相关 (均P <0 .0 5 ) ,调整与CRP相关的CHD危险因素后 ,IgG与CRP仍呈正相关 (P <0 .0 5 )。治疗后AMI组、AMI组中Hp(+)者CRP明显低于治疗前 (P <0 .0 5 ) ,且仍与IgG呈正相关 (P <0 .0 5 )。结论 :Hp感染与AMI之间存在明显的相关性 ,与血脂。
Objectire:To investigate the relations between helicobacter pylori(Hp) infection and acute myocardial infarction.Methods: The concentration of Hp specific IgG IgM antibody were measured in 51 patients with acute myocardial infarction(AMI group), 42 patients with old myocardial infarction (OMI group) and 31 normal controls (NC group). Simultaneously, the changes and relationships between C reative protein(CRP)?serum lipids and Hp infection were determined in the three groups.Results: 76.47 % of the AMI group were seropositive for Hp, and the average concentration (O.D.) of IgG(IgM)antibody to Hp was significantly higher than that of the NC group(P< 0.05 ). The relation between the Hp infection and AMI was strong. The average concentration of IgG antibody to Hp, the levels of total cholesterol(TC), triglyceride (TG), low density lipoprotein cholesterol(LDL C) and CRP were significantly higher in the AMI group when compared with those in the NC group. Those who were Hp positive in the AMI group had not only significantly higher levels of CRP, and significantly lower levels of high density lipoprotein cholesterol (HDL C) than those who were Hp negative in the same group (P< 0.05 )but also than those who were Hp positive in the OMI group (P< 0.01 ). Correlation analysis revealed that the average concentration of IgG antibody to Hp was positively associated with the levels of CRP?TC and LDL C, but there was a negative relation with the levels of HDL C in the Hp positive patients of the AMI group. In the AMI group after treatment, the level of CRP was significantly lower than that before treatment, as well as in Hp positive patients of the AMI group(P< 0.05 ).Conclusion: There is a significant relation between Hp infection and AMI. There is a certain relation between serum lipids?C reative protein and Hp infection, too.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2002年第12期609-612,共4页
Journal of Clinical Cardiology
基金
贵州省科学基金资助项目 (No .黔科合字19991177号 )
关键词
冠状动脉疾病
心肌梗死
幽门螺杆菌
C-反应蛋白
脂质
Coronary disease
Myocardial infarction
Helicobacter pylori
C reative protein
Lipids
